2005
DOI: 10.1002/path.1873
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Morbilliviruses and human disease

Abstract: Morbilliviruses are a group of viruses that belong to the family Paramyxoviridae. The most instantly recognizable member is measles virus (MV) and individuals acutely infected with the virus exhibit a wide range of clinical symptoms ranging from a characteristic mild selflimiting infection to death. Canine distemper virus (CDV) and rinderpest virus (RPV) cause a similar but distinctive pathology in dogs and cattle, respectively, and these, alongside experimental MV infection of primates, have been useful model… Show more

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Cited by 95 publications
(100 citation statements)
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References 185 publications
(161 reference statements)
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“…Wild-type MV initially replicates in mononuclear cells in the alveolar lumen, the bronchus-associated lymphoid tissue and the regional lymph nodes of the respiratory tract, followed by viremia and systemic disease [19,22]. Although measles is associated with immune suppression, MV paradoxically induces a strong cellular and humoral immune response that efficiently clears the virus and results in lifelong immunity [23]. Human DC-SIGN 1 DCs transmit MV to lymphocytes [18,24] and DCs have been shown to become infected by MV in vivo in macaques [19].…”
mentioning
confidence: 99%
“…Wild-type MV initially replicates in mononuclear cells in the alveolar lumen, the bronchus-associated lymphoid tissue and the regional lymph nodes of the respiratory tract, followed by viremia and systemic disease [19,22]. Although measles is associated with immune suppression, MV paradoxically induces a strong cellular and humoral immune response that efficiently clears the virus and results in lifelong immunity [23]. Human DC-SIGN 1 DCs transmit MV to lymphocytes [18,24] and DCs have been shown to become infected by MV in vivo in macaques [19].…”
mentioning
confidence: 99%
“…Natural infections by all of these share common features, including lymphopenia and inhibition of lymphocyte proliferation in the acute phase (Griffin, 2007;Heaney et al, 2002;von Messling et al, 2003;Yanagi et al, 2006). Although live vaccines have effectively reduced the incidence of disease, the highly contagious morbilliviruses are still a major problem in human and veterinary medicine (Greene & Appel, 2006;Rima & Duprex, 2006). Like MV and RPV, CDV causes a typical acute infection characterized by virus replication in cells of the lymphoid system, with subsequent spread to tissues throughout the body.…”
mentioning
confidence: 99%
“…1f). Infection of the apical surface of ex vivo-cultured human corneal rim epithelium results in a limited infection Ocular complications such as corneal inflammation (keratitis) resulting from MV infection are commonly observed in the developing world, but little is known about the susceptibility of epithelial cells in the eye to MV infection (Rima & Duprex, 2006). Therefore, in order to extend observations of epithelial cell infection in the macaque model of measles, we examined the susceptibility of the RPE cell line and ex vivo-cultured corneal epithelium to the wildtype rMV IC323 EGFP.…”
mentioning
confidence: 99%