Morbilidad y mortalidad asociada a hospitalizaciones por influenza pandémica A (H1N1) 2009 en dos hospitales de la Región Metropolitana y evaluación de su impacto económico

Armstrong, Macarena; Fíca, Alberto; Dabanch, Jeannette; Olivares, Felipe; Fasce, Rodrigo; Triantafilo, Vjera

doi:10.4067/s0716-10182012000700014

Cited by 5 publications

(4 citation statements)

References 12 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lymphopenia (< 1 000/µL) and increased CRP in plasma (> 10 times the upper-normal value) have been previously described in the literature, demonstrating the systemic involvement of influenza infection (16, 20). In this study, altered renal function was frequently detected, but non-stringent criteria (“above normal values”) were used.…”

Section: Discussionmentioning

confidence: 66%

Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital

Fíca

Sotomayor

Fasce

et al. 2019

Rev Panam Salud Publica

Self Cite

View full text Add to dashboard Cite

Objective To 1) describe clinical characteristics of adult patients in Chile with severe acute respiratory infections (SARI) associated with influenza viruses, and 2) analyze virus subtypes identified in specimens collected from those patients, hospital resources used in clinical management, clinical evolution, and risk factors associated with a fatal outcome, using observational data from the SARI surveillance network (SARInet). Methods Adults hospitalized from 1 July 2011 to 31 December 2015 with influenza-associated SARI at a SARI sentinel surveillance hospital in Santiago were identified and the presence of influenza in all cases confirmed by reverse transcription polymerase chain reaction (RT-PCR), using respiratory samples. Results A total of 221 patients (mean age: 74.1 years) were hospitalized with influenza-associated SARI during the study period. Of this study cohort, 91.4% had risk factors for complications and 34.3% had been vaccinated during the most recent campaign. Pneumonia was the most frequent clinical manifestation, occurring in 57.0% of the cohort; other manifestations included influenza-like illness, exacerbated chronic bronchitis, decompensated heart failure, and asthmatic crisis. Cases occurred year-round, with an epidemic peak during autumn–winter. Both influenza A (H1N1pdm09 and H3N2) and B virus co-circulated. Critical care beds were required for 26.7% of the cohort, and 19.5% needed ventilatory assistance. Multivariate analysis identified four significant factors associated with in-hospital mortality: 1) being bedridden (adjusted odds ratio (aOR): 22.3; 95% confidence interval (CI): 3.0–164); 2) admission to critical care unit (aOR: 8.9; CI: 1.44–55); 3) Pa0 2 /Fi0 2 ratio < 250 (aOR: 5.8; CI: 1.02–33); and 4) increased serum creatinine concentration (> 1 mg/dL) (aOR: 5.47; CI: 1.20–24). Seasonal influenza vaccine was identified as a significant protective factor (aOR: 0.14; CI: 0.021–0.90). Conclusions Influenza-associated SARI affected mainly elderly patients with underlying conditions. Most patients evolved to respiratory failure and more than one-quarter required critical care beds. Clinical presentation was variable. Death was associated with host characteristics and disease-associated conditions, and vaccine was protective. Virus type did not influence outcome.

show abstract

Section: Discussionmentioning

confidence: 66%

Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital

Fíca

Sotomayor

Fasce

et al. 2019

Rev Panam Salud Publica

Self Cite

View full text Add to dashboard Cite

show abstract

“…Distinctively, a study conducted in Poland showed that chronic conditions have given cause for no adherence (23) . The correlation between presence of chronic disease(s) and acceptance of the vaccine in this study, is positive with respect to the prevention of morbidity and mortality associated with the pandemic virus, since certain chronic conditions commonly present in the elderly are risk factors for complications from infection with the A (H1N1), such as hospitalization and death (24) .…”

Section: Discussionmentioning

confidence: 94%

“…A study in Chile found that alcoholism is an aggravating factor in infection with Influenza A (H1N1) (24) .…”

Section: Discussionmentioning

confidence: 99%

Factors associated with vaccination against Influenza A (H1N1) in the elderly

Victor¹,

Gomes

Sarmento

et al. 2014

Rev. esc. enferm. USP

View full text Add to dashboard Cite

RESUmoObjetivou-se investigar os fatores sociodemográficos, clínicos, comportamentais e o recebimento de informações sobre a vacina contra a Influenza pandêmica A (H1N1) associados à vacinação de idosos. RESUmENEl objetivo fue investigar los factores sociodemográficos, clínicos, de comportamiento y el proceso de recepción de información, asociados a la vacunación contra la influenza pandémica A(H1N1) en adultos mayores. Corresponde a un estudio cuantitativo y transversal en el cual participaron 286 adultos mayores residentes en Fortaleza, CE, Brasil. La asociación entre variables se analizó mediante la prueba de chicuadrado de Pearson, considerándose un nivel de significación de 95% (p ≤ 0,05). Los resultados señalaron que, a diferencia de las características sociodemográficas, muchos aspectos clínicos, de comportamiento y relacionados con la entrega de información presentaron una correlación estadísti-camente significativa con la adhesión a la vacuna contra la influenza A (H1N1). Estos resultados podrán ser utilizados en estrategias de control y prevención de la infección por el subtipo viral en la población estudiada, incluso, en otras enfermedades inmunoprevenibles y sobre todo en posibles pandemias futuras.

show abstract

“…Esta alta frecuencia contrasta de sobremanera con nuestros propios datos. Así, en la primera ola, no observamos caso alguno de IRA con TRR en 16 pacientes atendidos en nuestro hospital 5 ni entre los 49 casos internados y registrados con influenza A H1N1pdm09 entre julio del 2011 y fines del 2015, según los registros de nuestra institución como centro de vigilancia de infección respiratoria aguda grave. Solo detectamos los dos pacientes de esta comunicación, estableciendo una frecuencia histórica de 4%.…”

Section: Discussionunclassified

Glomerulonefritis aguda con requerimiento de diálisis asociada a influenza A H1N1pdm09: Comunicación de dos casos

Aceituno

Fíca

Fasce

et al. 2017

Rev. chil. infectol.

Self Cite

View full text Add to dashboard Cite

Acute glomerulonephritis with hemodialysis requirement secondary to influenza A H1N1pdm09 infection. Report of two cases Acute renal failure (ARF) requiring hemodialysis is not common among patients affected by influenza. We report two unvaccinated adult patients with smoking habit, which were admitted with severe influenza A H1N1pdm09 that evolved with shock and required mechanical ventilation. Both patients developed progressive renal failure with oliguria/anuria, associated with urinary of inflammatory sediment with proteinuria, microhematuria and in one case also with hypocomplementemia, suggesting acute glomerulonephritis. Renal replacement therapy (RRT) was required in both cases. In one patient, who died of late complications, sequencing of the HA1 segment revealed the previously described D222N mutation associated to severe cases. ARF with RRT appears to be an uncommon complication of patients hospitalized for influenza A H1N1pdm09 and may be secondary to acute glomerulonephritis.

show abstract

Morbilidad y mortalidad asociada a hospitalizaciones por influenza pandémica A (H1N1) 2009 en dos hospitales de la Región Metropolitana y evaluación de su impacto económico

Cited by 5 publications

References 12 publications

Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital

Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital

Factors associated with vaccination against Influenza A (H1N1) in the elderly

Glomerulonefritis aguda con requerimiento de diálisis asociada a influenza A H1N1pdm09: Comunicación de dos casos

Contact Info

Product

Resources

About