Morbidades maternas modificam a composição nutricional do leite humano? uma revisão sistemática

Amaral, Yasmin Notarbartolo di Villarosa do; Moreira, Maria Elisabeth Lopes; Silva, Leila Maria Lopes da; Soares, Fernanda Valente Mendes; Moreira, Maria Elisabeth Lopes

doi:10.1590/1413-81232018247.18972017

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…Previous studies have documented this association as positive, but only in colostrum, not mature milk, or in populations with a large proportion of overweight and obese women [25,26]. Fat content is indeed known to be the most variable macronutrient in breast milk and has been attributed to either anthropometric or genetic maternal factors, which may explain our differing results from previous studies [27][28][29]. Our study provides new insight into the factors associated with fat content, since our data were adjusted for milk volume, which may be a very important factor in influencing fat concentration in mothers' milk.…”

Section: Discussioncontrasting

confidence: 69%

Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study

Rigourd

Lopera

Cata³

et al. 2020

Nutrients

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Most studies assessing the macronutrient content of human milk are published retrospectively using analyzers that fail to determine sodium content and do not take into account the role of volume in milk composition. We aimed to describe macronutrient content and sodium content in human milk over time, observe any associations between them, and determine the factors associated with the evolution of milk composition. A prospective, longitudinal, monocentric study was undertaken. Contents of protein, fat, and lactose of 102 milk samples from 40 mothers were determined using a human milk analyzer and that of sodium with a flame spectrophotometer. Milk volumes along with clinical data were recorded. Protein content in the fourth quartile of volume was significantly lower than that in the first three, suggesting the existence of a volume threshold for protein content at approximately 445 mL. After multivariate analysis, it was found that maternal age, average volume, and lactation period remained significantly associated with protein content, maternal age remained significantly associated with fat content, and only average volume with sodium content. In consideration of previous findings along with our data, we suggest that extra care should be taken with fortification for feeding preterm infants when the mother’s milk volume is greater than 400–450 mL.

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Section: Discussioncontrasting

confidence: 69%

Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study

Rigourd

Lopera

Cata³

et al. 2020

Nutrients

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“…Among overweight women, a reduction of lactose synthesis can explain in part the higher content of fat in human milk. They have higher blood concentration of triglycerides and increased oxidative stress [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…The literature has controversially pointed out a possible influence of maternal morbidities such as diabetes mellitus and arterial hypertension on the nutritional content of human milk [ 10 , 13 , 19 , 23 ]. Our results showed that maternal arterial hypertension increased the amount of energy and lipid value in human milk.…”

Section: Discussionmentioning

confidence: 99%

“…The nutritional composition of human milk may be influenced by some maternal factors, such as the nutritional status of the pregnant woman [ 6 ], maternal age [ 7 ], maternal food intake [ 8 ], the lactation stage [ 9 , 10 ], circadian physiology, duration of breastfeeding (fraction emulsion, suspension or solution) [ 4 ], behavioral habits (smoking and alcohol) [ 11 , 12 ], maternal illnesses (hypertension and diabetes mellitus) [ 13 ] and the sex of the child [ 14 ], among others. Although studies discussing the potential elements associated with the nutritional composition of human milk cover a wide range of subjects, the results are not conclusive.…”

Section: Introductionmentioning

confidence: 99%

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What Are the Maternal Factors that Potentially Intervenes in the Nutritional Composition of Human Milk?

et al. 2021

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Background: To evaluate the potential factors associated with the nutritional composition of human milk of puerperal women. Methods: cross-sectional study, conducted between March 2016 and August 2017, with 107 women, selected in a Tertiary Health Care Tertiary Health Facility of the Unified Health System (SUS) in the Municipality of Rio de Janeiro. Data were collected two months after delivery. The dependent variable of the study was the nutritional composition of human milk. We divided the independent variables into hierarchical levels: distal (age, schooling, parity and pregestational nutritional status), intermediate (number of prenatal visits and gestational weight gain) and proximal (alcohol consumption, smoking, diabetes mellitus and hypertension). For data analysis, we applied the multiple linear regression, centered on the hierarchical model. Only the variables associated with the nutritional composition of breast milk remained in the final model at a 5% level of significance. Results: The nutritional composition of human milk yielded by women with pregestational overweight, smokers and hypertensive had higher amounts of lipids and energy. Conversely, women with gestational weight gain below the recommended had lower amounts of these components. Conclusion: The evaluation of factors associated with the nutritional composition of human milk is extremely important to assist post-partum care practices. In this study, we observed that lipid and energy contents were associated to pregestational nutritional status, gestational weight gain, smoking and hypertension.

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“…However, it was reported that diabetes mellitus [72][73][74], overweight [75,76] or hypertension [77] of the lactating mother has an impact on the nutritional composition of milk. A summary of the main trends observed in the nutritional composition of mother's milk was presented by Amaral and coworkers [78] as well as the systematic review by Peila and coworkers [79].…”

Section: Maternal Morbidities and Their Impact On Fucosylation Of Diementioning

confidence: 99%

The Impact of Dietary Fucosylated Oligosaccharides and Glycoproteins of Human Milk on Infant Well-Being

Orczyk-Pawiłowicz

Lis-Kuberka

2020

Nutrients

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Apart from optimal nutritional value, human milk is the feeding strategy to support the immature immunological system of developing newborns and infants. The most beneficial dietary carbohydrate components of breast milk are human milk oligosaccharides (HMOs) and glycoproteins (HMGs), involved in both specific and nonspecific immunity. Fucosylated oligosaccharides represent the largest fraction of human milk oligosaccharides, with the simplest and the most abundant being 2′-fucosyllactose (2′-FL). Fucosylated oligosaccharides, as well as glycans of glycoproteins, as beneficial dietary sugars, elicit anti-adhesive properties against fucose-dependent pathogens, and on the other hand are crucial for growth and metabolism of beneficial bacteria, and in this aspect participate in shaping a healthy microbiome. Well-documented secretor status related differences in the fucosylation profile of HMOs and HMGs may play a key but underestimated role in assessment of susceptibility to fucose-dependent pathogen infections, with a potential impact on applied clinical procedures. Nevertheless, due to genetic factors, about 20% of mothers do not provide their infants with beneficial dietary carbohydrates such as 2′-FL and other α1,2-fucosylated oligosaccharides and glycans of glycoproteins, despite breastfeeding them. The lack of such structures may have important implications for a wide range of aspects of infant well-being and healthcare. In light of the above, some artificial mixtures used in infant nutrition are supplemented with 2′-FL to more closely approximate the unique composition of maternal milk, including dietary-derived fucosylated oligosaccharides and glycoproteins.

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Morbidades maternas modificam a composição nutricional do leite humano? uma revisão sistemática

Cited by 10 publications

References 21 publications

Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study

Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study

What Are the Maternal Factors that Potentially Intervenes in the Nutritional Composition of Human Milk?

The Impact of Dietary Fucosylated Oligosaccharides and Glycoproteins of Human Milk on Infant Well-Being

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