volume 93, issue 0, P2-S20-3 2020
DOI: 10.1254/jpssuppl.93.0_2-s20-3
View full text
|
|
Share

Abstract: Many studies suggest opioid receptor (OPr) dimerization modulates the pharmacological properties of opiates. Specifically, heteromerization between OPr types has been reported to lead to changes in intracellular signaling. Thus, ligands targeting heteromers are expected to be novel therapeutic targets with reduced side effects. The heteromers of mu (MOPr) and delta (DOPr) are detected in brain regions involved in pain processing. By highthrough-put screening, CYM51010 was identified as a MOPr-DOPr-biased ligan…

Expand abstract

Search citation statements

Order By: Relevance

Citation Types

0
0
0

Paper Sections

0
0
0
0
0

Publication Types

0
0
0
0

Relationship

0
0

Authors

Journals