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citations
Cited by 176 publications
(131 citation statements)
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References 76 publications
(101 reference statements)
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“…Tic disorders including TS often are associated with anxiety disorders, mood disorders including major depression and phobias. 34,35 In the present study, Slitrk1-deficient mice displayed elevated anxiety-like behavior that was attenuated by the administration of clonidine, a drug frequently used to treat patients with TS. These results suggest possible association of the elevated anxiety-like behavior induced by the dysfunction of Slitrk1 and the symptoms of TS.…”
Section: Discussionmentioning
confidence: 52%
“…Tic disorders including TS often are associated with anxiety disorders, mood disorders including major depression and phobias. 34,35 In the present study, Slitrk1-deficient mice displayed elevated anxiety-like behavior that was attenuated by the administration of clonidine, a drug frequently used to treat patients with TS. These results suggest possible association of the elevated anxiety-like behavior induced by the dysfunction of Slitrk1 and the symptoms of TS.…”
Section: Discussionmentioning
confidence: 52%
“…1 Although Tourette's syndrome (TS) is a frequent developmental tic disorder (1% of the population), 2 descriptions of suicide in this population are scant. [3][4][5][6][7][8][9][10] This is intriguing, because neuropsychiatric disorders occur in around 90% of TS patients attending specialized clinics, 11 and approximately one third of them show depression, 3,12 bipolar disorder, 3,13 or impulsive self-injurious behavior 14 that may predispose to suicidal behavior. Here, we report a case series of TS patients who completed suicide or attempted suicide and a literature review.…”
mentioning
confidence: 99%
“…12 Berthier et al 52 identified a dysfunction of the relation between the extrapyramidal and the limbic systems. In fact, manic episodes are observed in other pathologies that involve subcortical structures, such as Huntington's disease.…”
Section: Ocd and Other Anxiety Disordersmentioning
confidence: 99%
“…Depression is often associated with increased severity of tics, sleep disorders and ADHD. 12 Etiopathogenesis is multifactorial. Robertson et al 49 found that children with TS had more depressive symptoms than controls.…”
Section: Mood Disordersmentioning
confidence: 99%
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