Abstract:Diabetic neuropathy (DN) is a common complication of type 2 diabetes characterized by peripheral nerve damage and sensory loss. Dorsal root ganglion (DRG) sensory neurons require axonal mitochondrial transport to produce axonal ATP for neuronal function. In DN, DRG neurons exhibit axonal mitochondrial dysfunction and bioenergetic failure. A correlation between DN progression and dyslipidemia suggests that increased plasma saturated fatty acids (FAs) and decreased unsaturated FAs may play a role in the progress… Show more
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