1997
DOI: 10.1590/s0100-879x1997000500016 View full text |Buy / Rent full text
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Abstract: Different levels of insulin sensitivity have been described in several animal models of obesity as well as in humans. Monosodium glutamate (MSG)-obese mice were considered not to be insulin resistant from data obtained in oral glucose tolerance tests. To reevaluate insulin resistance by the intravenous glucose tolerance test (IVGTT) and by the clamp technique, newborn male Wistar rats (N = 20) were injected 5 times, every other day, with 4 g/kg MSG (N = 10) or saline (control; N = 10) during the first 10 days … Show more

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“…The decreased HSL activity and mRNA expression, found in adipose tissue of our MSG-treated rats also supports this conclusion, since conditions of hyperinsulinemia and decreased insulin sensitivity, like that taking place during late pregnancy, are known to have the opposite effect on these variables. 21 Enhanced insulin sensitivity in 1 month old MSG-rats may occur despite hyperinsulinemia and insulin resistance being reported in adult MSG-rats, 51 since a similar transient insulin hypersensitivity followed by decreased insulin responsiveness in white adipose tissue has been reported to occur in both VMH-induced obesity 52 and obese Zucker rats. 53 The present ®ndings do not allow us to establish the order of the different factors contributing to the later development of obesity in the MSG rats.…”
Section: Discussionmentioning
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“…The decreased HSL activity and mRNA expression, found in adipose tissue of our MSG-treated rats also supports this conclusion, since conditions of hyperinsulinemia and decreased insulin sensitivity, like that taking place during late pregnancy, are known to have the opposite effect on these variables. 21 Enhanced insulin sensitivity in 1 month old MSG-rats may occur despite hyperinsulinemia and insulin resistance being reported in adult MSG-rats, 51 since a similar transient insulin hypersensitivity followed by decreased insulin responsiveness in white adipose tissue has been reported to occur in both VMH-induced obesity 52 and obese Zucker rats. 53 The present ®ndings do not allow us to establish the order of the different factors contributing to the later development of obesity in the MSG rats.…”
Section: Discussionmentioning
“…And there are no reports exist of their mechanism of action in insulin resistance, obesity animal models. We investigated the effect of atorvastatin on glucose metabolism and insulin resistance and the mechanism of action in MSG-induced obese mice, a model of T2DM with obesity, hyperinsulinemia, insulin resistance, hyperlipidemia and hyperglycemia [24] . Atorvastatin significantly inhibited the plasma glucose and decreased the plasma insulin level and the HOMA-IR index but increased the ISI in obese mice.…”
Section: Discussionmentioning
“…Neonate male Wistar rats were subcutaneously injected during the first 5 days of life with MSG at a dose of 4 g/kg of body weight (BW) (Olney 1969, Hirata et al 1997. Control animals received equimolar saline solution.…”
Section: Animals and Obesitymentioning
“…Regarding this matter, subdiaphragmatic vagotomy (VAG) has been performed to attenuate the hyperinsulinemia in monosodium l-glutamate (MSG)-treated rats and other obese models such as Wistar fatty models (Yamatani et al 1998, Balbo et al 2000. The MSG rat is an interesting model that reconciles increased parasympathetic activity, hyperinsulinemia, and obesity, among other components of the metabolic syndrome, mimicking the disorders observed in obese individuals (Hirata et al 1997, Dolnikoff et al 2001, Karlen-Amarante et al 2012.…”
Section: Introductionmentioning