Mononuclear Copper(II) Halide Complexes with Tetradentate N₃S‐Coordinate Ligands: Synthesis, Structures and Bioactivities

Abstract

A series of mononuclear copper(II) complexes [Cu(bdmpe/bpmpe)X]Y [bdmpe= N,N‐bis((3,5‐dimethyl‐1H‐pyrazol‐1‐yl)methyl)‐2‐(phenylthio)ethan‐1‐amine, Y=PF6−, X=Cl 1, Br 3 and Y=BF4−, X=Cl 2, Br 4; bpmpe=N,N‐bis((1H‐pyrazol‐1‐yl)methyl)‐2‐(phenylthio)ethan‐1‐amine; Y=PF6−, X=Cl 5, Br 7 and Y=BF4−, X=Cl 6, Br 8] have been synthesized by the reaction of copper halides with ligands bdmpe/bpmpe in presence of Y and characterized. Single crystal X‐ray crystallography study indicates that complexes are mononuclear with distorted square pyramidal geometry. Complexes 1 and 7 show supramolecular dimeric nature due to short intermolecular interactions. The antimicrobial activity of all complexes were investigated against Gram positive (Bacillus subtilis, Streptococcus aureus) and Gram negative (Escherichia coli, Pseudomonas aeruginosa) bacterial strain by agar well dilution method and have demonstrated significant antimicrobial activity of the compounds. The studies on the interaction of complexes and DNA by agarose gel electrophoresis method revealed that the complexes can effectively cleave the circular plasmid DNA at very low concentrations.

Binary and Ternary Zinc(II) Complexes of Acyl Pyrazolones: Synthesis, Spectroscopic Analysis, Crystal Structure and Antimalarial Activity

“…The angles of the O(2)–Zn(1)–O(1), O(3)–Zn(1)–O(1), O(1)–Zn(1)–N1), O(1)–Zn(1)–N(2), O(2)–Zn(1)–O(4), O(3)–Zn(1)–O(4), O(4)–Zn(1)–N1) and O(4)–Zn(1)–N(2) are 86.16(10)°, 85.82(9)°, 95.29(11)°, 94.34(10)°, 87.54(10) °, 84.68(9) °, 93.03(11) ° and 96.28(10)° respectively, which are deviated from 90° angle between axial line and equatorial plane. Therefore geometry around the zinc ion in the complex is distorted octahedral . In the Complex 2 packing system inter molecule H‐bond is shown between oxygen atom (O4) of p‐chloro benzoyl of PCBPMP and a hydrogen atom (H3) of 2 2′‐bipyridine (Figure ).…”

“…The angle O(1)‐Zn(1)‐O(1)’, O(2)‐Zn(1)‐O(2)’ and O(46)‐Zn(1)‐O(46)’ are 180.0(3)°, 180.0(3)° and 180.0(4)° respectively, which are similar to the theoretical value of 180° . All these observations implied that the geometry around the Zn1 elongated distorted octahedron . The crystallographic data of the complex is given in table .…”

“…The angles O(2)‐Zn‐O(2)’, O(1)‐Zn‐O(1)’ and O(3)‐Zn‐O(3)’ are exactly 180.00°, which shows no deviation from theoretical value, where angles O(2)‐Zn‐O(3) and O(2)‐Zn‐O(3)’ are 88.99° and 91.01°, respectively, which reach around to 90°. Therefore, the given coordination geometry around the Zn II center can be defined as octahedral geometry .…”