Biochemical Pharmacology volume 78, issue 10, P1340-1349 2009 DOI: 10.1016/j.bcp.2009.07.003 View full text
S.J.S. Flora, Ashish Mehta

Abstract: The ability of human embryonic stem (ES) cells to differentiate into the three germ layers has proposed its application in studying human developmental toxicity in vitro. In the current study we investigated if the prompted application could be utilized to evaluate the efficacy of a newly developed arsenic antidote, monoisoamyl dimercaptosuccinic acid (MiADMSA) against arsenic (III) and if the results obtained in vitro were in concordance with the animal model for studying developmental toxicity. On the basis …

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