Monodispersed microfluidic droplet generation by shear focusing microfluidic device

Tan, Yung Chieh; Cristini, Vittorio; Lee, Abraham P.

doi:10.1016/j.snb.2005.06.008

Cited by 287 publications

(239 citation statements)

References 30 publications

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“…Droplet size decreased with increasing flow rate ratio ( Figure 1B,C), as was expected based on published data. 35,36 Moreover, at constant flow rate ratio, droplet size increased with microchannel width. Notably, at the same flow rate ratio, droplet dimensions do not change significantly with water flow rate.…”

Section: ■ Results and Discussionmentioning

confidence: 96%

Microfluidic Synthesis of Cell-Type-Specific Artificial Extracellular Matrix Hydrogels

2013

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Droplet microfluidic technology is applied for the high-throughput synthesis via Michael-type addition of reactive, micrometer-sized poly(ethylene glycol) (PEG) hydrogels ("microgels") with precisely controlled dimension and physicochemical properties. A versatile chemical scheme is used to modify the reactive PEG microgels with tethered biomolecules to tune their bioactive properties for the bioreactor culture and manipulation of various (stem) cell types.

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Section: ■ Results and Discussionmentioning

confidence: 96%

Microfluidic Synthesis of Cell-Type-Specific Artificial Extracellular Matrix Hydrogels

2013

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“…Hence, satellite droplets are formed due to a combination of capillary relaxation and the speed of breakdown of this capillary. 45 …”

Section: A Shear Forces and Interfacial Tensionmentioning

confidence: 99%

Droplet confinement and leakage: Causes, underlying effects, and amelioration strategies

2015

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The applicability of droplet-based microfluidic systems to many research fields stems from the fact that droplets are generally considered individual and selfcontained reaction vessels. This study demonstrates that, more often than not, the integrity of droplets is not complete, and depends on a range of factors including surfactant type and concentration, the micro-channel surface, droplet storage conditions, and the flow rates used to form and process droplets. Herein, a model microfluidic device is used for droplet generation and storage to allow the comparative study of forty-four different oil/surfactant conditions. Assessment of droplet stability under these conditions suggests a diversity of different droplet failure modes. These failure modes have been classified into families depending on the underlying effect, with both numerical and qualitative models being used to describe the causative effect and to provide practical solutions for droplet failure amelioration in microfluidic systems. V C 2015 AIP Publishing LLC.

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“…Since the generation of droplets with a predictable and reproducible size and size distribution determines their potential applications (including the synthesis of polymer colloids), several research groups have explored various aspects of the process of emulsification (Seo et al 2005a;Xu et al 2005;Zhang et al 2006;Cygan et al 2005;El-Ali et al 2005;Garstecki et al 2005a;Hudson et al 2005;Jensen and Lee 2004;Khan et al 2004;Song et al 2003;Zheng and Ismagilov 2005;Zheng et al 2003) . It has been observed that the size of droplets is controlled by the design of the microfluidic device (Sugiura et al 2002a, b;Tan et al 2006), the properties of liquids, and the rates of flow of two immiscible phases (Cramer et al 2004;GananCalvo 1998;Ganan-Calvo and Gordillo 2001;Garstecki et al 2004Garstecki et al , 2005aGarstecki et al , 2005bGarstecki et al , 2006Thorsen et al 2001;Serra et al 2007;Tice et al 2003;Ward et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Emulsification in a microfluidic flow-focusing device: effect of the viscosities of the liquids

Nie

Seo

et al. 2008

Microfluid Nanofluid

325

236

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We report the results of a comparative study of microfluidic emulsification of liquids with different viscosities. Depending on the properties of the fluids and their rates of flow, emulsification occurred in the dripping and jetting regimes. We studied the characteristic features and typical dependence of the size and of the size distribution of droplets in each regime. For each liquid, we identified a range of hydrodynamic conditions promoting generation of highly monodisperse droplets. Viscosity played an important role in emulsification: highly viscous liquids were emulsified into larger droplets with lower polydispersity. Although it was not possible to provide a unified scaling for the volumes of the droplets, our results suggest that the break-up dynamics of the lower viscosity fluids resembles the rate-of-flow-controlled break-up, as reported earlier for the formation of bubbles in flow-focusing geometries [Garstecki P, Stone HA, Whitesides GM (2005) Phys Rev Lett 94:164501]. The results of this study can be helpful for a rationalized selection of liquids for the controlled formation of droplets with a predetermined size and with a narrow distribution of sizes.

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Monodispersed microfluidic droplet generation by shear focusing microfluidic device

Cited by 287 publications

References 30 publications

Microfluidic Synthesis of Cell-Type-Specific Artificial Extracellular Matrix Hydrogels

Microfluidic Synthesis of Cell-Type-Specific Artificial Extracellular Matrix Hydrogels

Droplet confinement and leakage: Causes, underlying effects, and amelioration strategies

Emulsification in a microfluidic flow-focusing device: effect of the viscosities of the liquids

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