Monodisperse Dual Plasmonic Au@Cu_2–xE (E= S, Se) Core@Shell Supraparticles: Aqueous Fabrication, Multimodal Imaging, and Tumor Therapy at in Vivo Level

Abstract

We herein report aqueous fabrication of well-defined Au@CuE (E = S, Se) core@shell dual plasmonic supraparticles (SPs) for multimodal imaging and tumor therapy at the in vivo level. By means of a modified self-limiting self-assembly based strategy, monodisperse core@shell dual plasmonic SPs, including spherical Au@CuS SPs, Au@CuSe SPs, and rod-like Au@CuS SPs, are reliably and eco-friendly fabricated in aqueous solution. Due to plasmonic coupling from the core and shell materials, the as-prepared hybrid products possess an extremely large extinction coefficient (9.32 L g cm for spherical Au@CuS SPs) at 808 nm, which endows their excellent photothermal effect. Furthermore, the hybrid core@shell SPs possess the properties of good biocompatibility, low nonspecific interactions, and high photothermal stability. So, they show favorable performances for photoacoustic imaging and X-ray computed tomography imaging as well as photothermal therapy of tumors, indicating their application potentials in biological field.

UCNP–Bi2Se3 Upconverting Nanohybrid for Upconversion Luminescence and CT Imaging and Photothermal Therapy

“…For the photothermal conversion efficiency, the temperature of a UCNP–Bi 2 Se 3 solution (Bi 3+ : 100 μg mL −1 ) during a laser heating/cooling cycle was monitored. The photothermal conversion efficiency was calculated according to the equations reported previously …”

“…The photothermal conversion efficiencyw as calculated according to the equations reported previously. [22] Cytotoxicity assessment and live/dead cell staining:A 549 cancer cells (1 10 4 cells per well) were seeded and cultured in 96-well plates overnight, followed by incubation with different concentrations of the UCNP-Bi 2 Se 3 nanohybrid for 24 h. The cell viabilities were measured by the standard MTT assay.F or the assessment of the photothermal effect, the procedure was identical to that of the cytotoxicity assessment, except that the samples were subjected to 808 nm NIR irradiation (1.5 Wcm À2 ,6 min per well) before adding MTT to the cell media. In addition, live/dead cell staining was performed to further evaluate the anticancer efficiency of the UCNP-Bi 2 Se 3 nanohybrid in cells, for which the calcein AM/PI costaining method was adopted.…”

Coupling Resonances of Surface Plasmon in Gold Nanorod/Copper Chalcogenide Core−Shell Nanostructures and Their Enhanced Photothermal Effect

“…Combination of metal NPs with vacancy‐doped plasmonic semiconductor nanocrystals together will open the access to unexplored phenomena resulting from the coupling between the collective electronic oscillation at surface of metal NPs and the hole oscillation in the neighboring semiconductors . Many metal‐semiconductor hetero‐nanostructures have been synthesized and the plasmonic properties have been investigated . Jiang et al.…”

Chiral Semiconductor Nanoparticles for Protein Catalysis and Profiling

“…The d/l-QDs can be used as photocatalysts to cleave proteins.N otably,t he l-QDs displayed the highest catalytic performance under left-circularly polarized light irradiation. These chiral NPs with deformations of the crystal lattices may be extended to other nanomaterials with tailorable chiroptical properties.Nanocrystalline copper sulfide (Cu 2Àx S) is ap -type semiconductor and am aterial of particular interest due to its promising applications in biomedicine, [16] and optoelectronic conversion (photovoltaics,p hotocatalysis,a nd thermoelectrics). [8] Chiral inorganic NPs have triggered great interest due to their easy synthesis and their tremendous applications including chiral sensing, [9] chiral separation, enantioselective catalysis,a nd advanced photonic devices.…”

“…Nanocrystalline copper sulfide (Cu 2Àx S) is ap -type semiconductor and am aterial of particular interest due to its promising applications in biomedicine, [16] and optoelectronic conversion (photovoltaics,p hotocatalysis,a nd thermoelectrics). [17] Endowing chirality to Cu 2Àx Sn anomaterials could enable aw ider range of potential applications for chiral Cu 2Àx Si nb iology,c hemistry,a nd physics.H owever, to date,n op ublications are available on the synthesis and application of chiral Cu 2Àx Snanomaterials.…”