Monocyte volumetric parameters and lymph index are increased in SARS‐CoV‐2 infection

Zeng, Xiaoqian; Xing, Hui; Yan, Wei; Tang, Zhaoming; Lü, Xiao; Wang, Zhao; Liu, Yuying; Xu, Liang; Hu, Lihua; Wang, Lin; Xu, Dongsheng

doi:10.1111/ijlh.13323

Cited by 23 publications

(26 citation statements)

References 13 publications

(20 reference statements)

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“…In previous studies evaluating complete blood count parameters in COVID-19 patients, NEU, LYM, PLT counts were also found to be lower in comparison with the control group 17 . Similar to our results, another study evaluated hemoglobin, the percentage of neutrophils, lymphocytes and especially monocytes and found higher parameters in COVID-19 patients 18 , 19 . Although neutropenia and lymphopenia were frequently found in studies investigating complete blood count parameters in COVID-19 patients, monocytosis was only occasionally detected 20 .…”

Section: Discussionsupporting

confidence: 90%

Usefulness of laboratory parameters and chest CT in the early diagnosis of COVID-19

Çolak

Oncel

Altın

et al. 2022

Rev. Inst. Med. trop. S. Paulo

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In the present study, the importance of laboratory parameters and CT findings in the early diagnosis of COVID-19 was investigated. To this end, 245 patients admitted between April 1 st , and May 30 th , 2020 with suspected COVID-19 were enrolled. The patients were divided into three groups according to chest CT findings and RT-PCR results. The non-COVID-19 group consisted of 71 patients with negative RT-PCR results and no chest CT findings. Ninety-five patients with positive RT-PCR results and negativechest CT findings were included in the COVID-19 group; 79 patients with positive RT-PCR results and chest CT findings consistent with COVID-19 manifestations were included in COVID-19 pneumonia group. Chest CT findings were positive in 45% of all COVID-19 patients. Patients with positive chest CT findings had mild (n=30), moderate (n=21) andor severe (n=28) lung involvement. In the COVID-19 group, CRP levels and the percentage of monocytes increased significantly. As disease progressed from mild to severe, CRP, LDH and ferritin levels gradually increased. In the ROC analysis, the area under the curve corresponding to the percentage value of monocytes (AUC=0.887) had a very good accuracy in predicting COVID-19 cases. The multinomial logistic regression analysis showed that CRP, LYM and % MONO were independent factors for COVID-19. Furthermore, the chest CT evaluation is a relevant tool in patients with clinical suspicion of COVID-19 pneumonia and negative RT-PCR results. In addition to decreased lymphocyte count, the increased percentage of monocytes may also guide the diagnosis.

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Section: Discussionsupporting

confidence: 90%

Usefulness of laboratory parameters and chest CT in the early diagnosis of COVID-19

Çolak

Oncel

Altın

et al. 2022

Rev. Inst. Med. trop. S. Paulo

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“…Individuals with these kinds of monocytes required long‐term hospitalization and ICU admission. Also, in a study by Zeng et al, 25 they observed that monocyte distribution width (MDW) was significantly increased in COVID‐19 patients than the control group. In addition, Zhou et al observed that Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) + Th1 cells and CD14 + CD16 + monocytes accelerated the immune response and exacerbated the COVID‐19 disease through overexpression of IL‐6 40 .…”

Section: Monocytes and Macrophagesmentioning

confidence: 92%

“…According to the results of a meta‐analysis conducted by Henry et al, the WBC count was significantly higher in non‐survivors COVID‐19 patients in comparison with survivors. Their meta‐analysis also showed that the WBC count increases mildly in people with severe COVID‐19, while a significant increase in WBC count may predict a poor clinical prognosis 24‐26 . All the current evidences highly suggest that although WBC count can be used as a predictor factor for severer COVID‐19 condition, factors such as the onset of the disease, underlying diseases, severity of the disease, and RT‐PCR results should be taken into account.…”

Section: White Blood Cellsmentioning

confidence: 98%

COVID‐19 and hematology findings based on the current evidences: A puzzle with many missing pieces

Karimi‐Shahri

Niazkar

Rad

2020

Int J Lab Hematology

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In December 2019, a new type of coronavirus was detected for the first time in Wuhan, Hubei Province, China. According to the reported data, the emerging coronavirus has spread worldwide, infecting more than fifty‐seven million individuals, leading to more than one million deaths. The current study aimed to review and discuss the hematological findings of COVID‐19. Laboratory changes and hematologic abnormalities have been reported repeatedly in COVID‐19 patients. WBC count and peripheral blood lymphocytes are normal or slightly reduced while these indicators may change with the progression of the disease. In addition, several studies demonstrated that decreased hemoglobin levels in COVID‐19 patients were associated with the severity of the disease. Moreover, thrombocytopenia, which is reported in 5%‐40% of patients, is known to be associated with poor prognosis of the disease. COVID‐19 can present with various hematologic manifestations. In this regard, accurate evaluation of laboratory indicators at the beginning and during COVID‐19 can help physicians to adjust appropriate treatment and provide special and prompt care for those in need.

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“…A total of 23 articles were initially detected with our search criteria, 20 of which were excluded after title, abstract, or full-text screening, because they either failed to provide MDW values in patients with and without SARS-CoV-2 infection (n = 15) or MDW values were not measured in patients with COVID-19 (n = 5). Thus, a total of three studies, with combined 452 subjects (143 with SARS-CoV-2 infection; 31.6%, range 6.0%-60.0%), were finally included in our pooled analysis [5][6][7] (Table 1). One study compared MDW in COVID-19 positive patients vs COVID-19 negative controls, 7 one study compared MDW in COVID-19 symptomatic and paucisymptomatic patients presenting to the emergency department, 6 and one study compared MDW in those with COVID-19 as opposed to upper respiratory tract infections.…”

mentioning

confidence: 99%

“…Thus, a total of three studies, with combined 452 subjects (143 with SARS-CoV-2 infection; 31.6%, range 6.0%-60.0%), were finally included in our pooled analysis [5][6][7] (Table 1). One study compared MDW in COVID-19 positive patients vs COVID-19 negative controls, 7 one study compared MDW in COVID-19 symptomatic and paucisymptomatic patients presenting to the emergency department, 6 and one study compared MDW in those with COVID-19 as opposed to upper respiratory tract infections. 5 In all three studies, the cutoff was set at a similar threshold (≥20 in two studies and ≥20.1 in the third, respectively), and MDW values were higher in patients with SARS-CoV-2 infection than those without, as shown in Figure 1.…”

mentioning

confidence: 99%

Pooled analysis of monocyte distribution width in subjects with SARS‐CoV‐2 infection

Lippi

Sanchís-Gomar

Henry

2021

Int J Lab Hematology

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Monocyte volumetric parameters and lymph index are increased in SARS‐CoV‐2 infection

Cited by 23 publications

References 13 publications

Usefulness of laboratory parameters and chest CT in the early diagnosis of COVID-19

Usefulness of laboratory parameters and chest CT in the early diagnosis of COVID-19

COVID‐19 and hematology findings based on the current evidences: A puzzle with many missing pieces

Pooled analysis of monocyte distribution width in subjects with SARS‐CoV‐2 infection

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