Monocyte subpopulations study in patients with plaque psoriasis

Costa, Mariana Carvalho; Rocha, Bruno de Oliveira; Paixão, Camilla S.; Oliveira, Maria de Fátima Santos Paim de; Mota, Lícia Maria Henrique da; Carvalho, Lucas P.

doi:10.1016/j.mehy.2017.05.031

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…The respiratory burst with reactive oxygen species generation, degranulation, and the formation of neutrophil extracellular traps from neutrophils have been discovered to contribute to the immunopathogenesis of psoriasis ( 10 ). Monocytes showed a significant increase in chemotactic response in psoriasis ( 66 ), and also produce some cytokines of major importance in psoriasis, such as IL-1, IL-6, and tumor necrosis factors, among others ( 67 ). Immune cells derived from monocytes, such as dendritic cells and macrophages, play a crucial role in psoriasis-like inflammation ( 68 , 69 ) These immune cells can secrete drivers of inflammation, such as IL-23, to promote the incidence of psoriasis ( 70 ).…”

Section: Discussionmentioning

confidence: 99%

“…This discrepancy might be explained by epidemiological confounding factors related to the study cohort. In addition, other studies have reported that immune cells derived from the skin might also play a crucial role in the incidence of psoriasis ( 65 , 67 ); hence, the causal relationship between these two cell types in skin lesions and psoriasis may need to be explored in the future. Although lymphocytes have been proven to be a key factor in the pathogenesis of psoriasis ( 3 , 72 ), the circulating lymphocyte count tends to decrease in patients with psoriasis, according to a previous study ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

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Exploring the association and causal effect between white blood cells and psoriasis using large-scale population data

et al. 2023

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IntroductionPsoriasis is a chronic inflammatory disease of the skin. A few studies have shown that psoriasis is an immune-mediated disease in which multiple immune cells play crucial roles. However, the association between circulating immune cells and psoriasis remains elusive.MethodsTo explore the role of circulating immune cells in psoriasis, 361,322 individuals from the UK Biobank (UKB) and 3,971 patients with psoriasis from China were included to investigate the association between white blood cells and psoriasis via an observational study. Genome-wide association studies (GWAS) and Mendelian randomization (MR) were used to evaluate the causal relationship between circulating leukocytes and psoriasis.ResultsThe risk of psoriasis increased with high levels of monocytes, neutrophils, and eosinophils (relative risks and 95% confidence intervals, respectively: 1.430 (1.291–1.584) for monocytes, 1.527 (1.379–1.692) for neutrophils, and 1.417 (1.294–1.551) for eosinophils). Upon further MR analysis, eosinophils showed a definite causal relationship with psoriasis (odds ratio of inverse-variance weighted: 1.386, 95% confidence intervals: 1.092–1.759) and a positive correlation with the psoriasis area and severity index (PASI) score (P = 6.6 × 10-5). The roles of the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR) in psoriasis were also assessed. More than 20,000 genetic variations associated with NLR, PLR, and LMR were discovered in a GWAS analysis using the UKB data. Following adjustment for covariates in the observational study, NLR and PLR were shown to be risk factors for psoriasis, whereas LMR was a protective factor. MR results indicated that there was no causal relationship between these three indicators and psoriasis; however, NLR, PLR, and LMR correlated with the PASI score (NLR: rho = 0.244, P = 2.1 × 10-21; PLR: rho = 0.113, P = 1.4 × 10-5; LMR: rho = -0.242, P = 3.5×10-21).DiscussionOur findings revealed an important association between circulating leukocytes and psoriasis, which is instructive for the clinical practice of psoriasis treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exploring the association and causal effect between white blood cells and psoriasis using large-scale population data

et al. 2023

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“…CD14 ++ CD16 neg cells are called classic monocytes; CD14 + CD16 ++ that resemble tissue macrophages are called nonclassical monocyte subsets; and CD14 ++ CD16 + represent an intermediate monocyte subset . In various inflammatory situations, such as asthma, colorectal cancer, psoriasis and rheumatoid arthritis, the frequency of distinct monocyte subpopulations increases during different phases of disease . For instance, in patients with rheumatoid arthritis or cardiovascular diseases, the frequency of intermediate monocytes is associated with a decreased response to specific therapies and can serve as a predictor of poor outcome …”

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confidence: 99%

Nonclassical monocytes: are they the next therapeutic targets in multiple sclerosis?

Ajami

Steinman

2018

Immunol Cell Biol

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CD86 Expression by Monocytes Influences an Immunomodulatory Profile in Asymptomatic Patients with Chronic Chagas Disease

et al. 2018

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In the chronic phase of Chagas disease, 60% of the patients develop the asymptomatic form known as indeterminate (IND). The remaining 30% of the patients develop a life-threatening form in which digestive and/or cardiac (CARD) alterations take place. The mechanisms underlying the development of severe forms of Chagas disease remain poorly understood. It is well known that interactions between immune cells such as monocytes and lymphocytes drive immune responses. Further, the co-stimulatory molecules CD80 and CD86 expressed by monocytes and subsets induce lymphocyte activation, thereby triggering cellular immune response. Here, we revealed, for the first time, the functional-phenotypic profile of monocytes subsets in Chagas disease. Using flow cytometry, we evaluated the effect of in vitro stimulation with Trypanosoma cruzi antigens on the expression of the co-stimulatory molecules CD80 and CD86 in different monocyte subsets of patients with IND and CARD clinical forms of Chagas disease. We also assessed the expression of toll-like receptor (TLR)-2, TLR-4, TLR-9, HLA-DR, IL-10, and IL-12 in the monocyte subsets and of CTLA-4 and CD28, ligands of CD80 and CD86, in T lymphocytes. CD86 expression in all monocyte subsets was higher in IND patients when compared with non-infected (NI) individuals. After stimulation with T. cruzi, these patients also showed a higher frequency of CD4+CTLA-4+ T lymphocytes than NI individuals. We found an association between CD80 and CD28, and between CD86 and CTLA-4 expression, with a high frequency of regulatory T (Treg) cells in IND patients. We proposed that CD86 may be involved in immunoregulation by its association with CTLA-4 in asymptomatic patients. CD86 and CTLA-4 interaction may influence Treg activation, and this could represent a new strategy to control inflammation and tissue damage.

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Monocyte subpopulations study in patients with plaque psoriasis

Cited by 6 publications

References 24 publications

Exploring the association and causal effect between white blood cells and psoriasis using large-scale population data

Exploring the association and causal effect between white blood cells and psoriasis using large-scale population data

Nonclassical monocytes: are they the next therapeutic targets in multiple sclerosis?

CD86 Expression by Monocytes Influences an Immunomodulatory Profile in Asymptomatic Patients with Chronic Chagas Disease

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