Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation

Huang, Shengping; Li, Shufeng; Fu, Jia J.; Wang, T. Tony; Yao, Xiaolan; Kumar, Anil; Liu, Gang; Fu, Mingui

doi:10.1074/jbc.m114.635870

Cited by 25 publications

(22 citation statements)

References 38 publications

(51 reference statements)

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“…The identity of MCPIP1 containing granules is still controversial. We recently found that MCPIP1-containing granules overlapped with GW182 and argonaute 2 (AGO2), which are molecular markers of GW-bodies, suggesting that MCPIP1 may functionally interact with microRNA effector pathways 38 . However, a recent study indicated that MCPIP1 was localized on ribosomes on endoplasmic reticulum 32 .…”

Section: Ccch Zinc Finger Proteinsmentioning

confidence: 99%

“…Similarly, monocyte chemotactic protein-induced protein 1 (MCPIP1) interacts with GW182, another core component of miRISC 38 . However, the functional significance of the interaction of these CCCH zinc finger proteins with miRISC is still an open question.…”

Section: Ccch Zinc Finger Proteinsmentioning

confidence: 99%

“…For example, MCPIP4 (also known as TFL and p34 and encoded by ZC3H12D ) is involved in the regulation of Il6 , Il1b , Tnf and Il2 mRNA decay through the targeting of their 3′ UTR 38–40 . The consequences of this regulation could be seen in MCPIP4-deficient mice, which produced elevated levels of IL-2, IL-6, TNF and IL-17A 40 .…”

Section: Regulation Of Cytokine Productionmentioning

confidence: 99%

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RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins

2016

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Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA splicing, polyadenylation, transportation, translation and decay. Several CCCH zinc finger proteins, such as tristetraprolin (TTP), roquin 1 and MCPIP1 (also known as regnase 1), are crucial for many aspects of immune regulation by targeting mRNAs for degradation and modulation of signalling pathways. In this Review, we focus on the emerging roles of CCCH zinc finger proteins in the regulation of immune responses through their effects on cytokine production, immune cell activation and immune homeostasis.

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Section: Ccch Zinc Finger Proteinsmentioning

confidence: 99%

Section: Ccch Zinc Finger Proteinsmentioning

confidence: 99%

Section: Regulation Of Cytokine Productionmentioning

confidence: 99%

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RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins

2016

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“…MCPIP1 seems to form a homodimer and a homotetramer upon binding to the targeted stem‐loop . However, MCPIP1 was shown to interact with MCPIP4 (Zc3h12d), and it is likely that they can form a heterotetramer in order to expand their range of substrates, gain specificity, or increase activity . MCPIP1 targets TRAF proteins by de‐ubiquitination and impairs their function in the inflammatory and immune response .…”

Section: Introductionmentioning

confidence: 99%

Involvement of PIN‐like domain nucleases in tRNA processing and translation regulation

2019

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Transfer RNAs require essential maturation steps to become functional. Among them, RNase P removes 5′ leader sequences of pre‐tRNAs. Although RNase P was long thought to occur universally as ribonucleoproteins, different types of protein‐only RNase P enzymes were discovered in both eukaryotes and prokaryotes. Interestingly, all these enzymes belong to the super‐group of PilT N‐terminal‐like nucleases (PIN)‐like ribonucleases. This wide family of enzymes can be subdivided into major subgroups. Here, we review recent studies at both functional and mechanistic levels on three PIN‐like ribonucleases groups containing enzymes connected to tRNA maturation and/or translation regulation. The evolutive distribution of these proteins containing PIN‐like domains as well as their organization and fusion with various functional domains is discussed and put in perspective with the diversity of functions they acquired during evolution, for the maturation and homeostasis of tRNA and a wider array of RNA substrates. © 2019 IUBMB Life, 2019 © 2019 IUBMB Life, 71(8):1117–1125, 2019

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“…Zc3h12d −/− mice synthesize increased amounts of IL‐2, IL‐6, and IL‐10 and overexpression of ZC3H12D results in a faster decay of IL‐2, IL‐6, IL‐10, TNF, IL‐17A mRNAs in Jurkat cells and destabilizes IL‐1β, IL‐6, and TNF transcripts in THP1 cells [Minagawa et al, , Zhang et al, ]. Recently, it was published that ZC3H12D interacts with ZC3H12A forming a protein complex present in the cytoplasm in granule‐like structures, enriched with markers typical for GW‐bodies [Huang et al, ].…”

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confidence: 99%

Intact NYN/PIN-Like Domain is Crucial for the Degradation of Inflammation-Related Transcripts by ZC3H12D

et al. 2016

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ZC3H12D belongs to a recently discovered family of proteins containing four members of which the most studied and best described is the RNase ZC3H12A (MCPIP1/Regnase-1). ZC3H12A is a crucial negative regulator of inflammation. It accelerates the turnover of transcripts of a spectrum of proinflammatory cytokines, as well as its own mRNA. The biological role of ZC3H12D is less clear, although it was shown that this member of ZC3H12 family is also involved in the regulation of inflammation. Here, we show that ZC3H12A and ZC3H12D recognize a set of common target mRNAs encoding proteins that play important roles in the course of the inflammation. Similarly to ZC3H12A, ZC3H12D participates in the 3'UTR-dependent regulation of the turnover of mRNAs encoding interleukin-6 (IL-6), tumor necrosis factor (TNF), and immediate early response 3 gene (IER3). The ZC3H12A mRNA is also among the identified ZC3H12D targets. Using the combination of immunofluorescence with single molecule RNA fluorescence in situ hybridization (smRNA FISH) we have shown that ZC3H12D protein interacts with the ZC3H12A transcript. The direct binding of these two molecules in vivo was further confirmed by RNA immunoprecipitation. Simultaneously, overexpression of ZC3H12D increases the turnover rate of transcripts containing ZC3H12A 3'UTR. Using reporter gene assays we have confirmed that the Asp95 residue present in the NYN/PIN-like domain is crucial for ZC3H12D biological activity. We have also revealed that ZC3H12D recognizes the same structural elements present in the 3'UTRs of the investigated transcripts, as ZC3H12A. J. Cell. Biochem. 118: 487-498, 2017. © 2016 Wiley Periodicals, Inc.

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Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation

Cited by 25 publications

References 38 publications

RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins

RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins

Involvement of PIN‐like domain nucleases in tRNA processing and translation regulation

Intact NYN/PIN-Like Domain is Crucial for the Degradation of Inflammation-Related Transcripts by ZC3H12D

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