Abstract:Monoclonal antibodies were raised against membrane glycoproteins prepared from rat liver using lentil-lectin affinity chromatography. Monoclonal antibodies to rat hepatocytes with three different characteristics were obtained and designated as HAM.1, HAM.2 and HAM.3. The binding characteristics of these three monoclonal antibodies were analysed by flow cytofluorography and indirect radioimmunoassay; HAM.3 recognized a membrane antigen restricted mainly to hepatocytes. However, most rat hepatoma cell lines test… Show more
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