Abstract:Synthetic opioids including fentanyl are the lead cause of opioid-related deaths in the United States. Current treatments for opioid overdose include the opioid receptor antagonist naloxone; however, naloxone is not as effective against highly potent opioids, has a relatively short half-life, and precipitates withdrawal symptoms. Monoclonal antibody (mAb) therapy offers a promising strategy to combat opioid-related overdoses. Opioid-specific mAb bind to target molecules in the bloodstream and inhibit them from… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.