Monoamine oxidase-B inhibitor protects degenerating spinal neurons, enhances nerve regeneration and functional recovery in sciatic nerve crush injury model

Hussain, Al-Shimali M.; Renno, Waleed M.; Sadek, Hanaa; Kayali, Noura M.; Alsalem, Aseel; Rao, Muddanna S.; Khan, Khalid M.

doi:10.1016/j.neuropharm.2017.10.020

Cited by 10 publications

(23 citation statements)

References 75 publications

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“…Moreover, Liao et al have proved that MAOA was involved in the development of adenocarcinoma. Prior study performed by Hussain et al and Tong et al elucidated the vital functions of MAOB on Alzheimer's disease and Parkinson's disease, but its function in some types of cancers such as endometrial carcinoma still remains unknown. To complete the understanding of the miR‐522 regulatory effect, we investigated the functions of MAOB, which was considered as a downstream target gene of miR‐522.…”

Section: Discussionmentioning

confidence: 99%

“…Prior study performed by Hussain et al 22 and Tong et al 23 of dual-luciferase reporter assay ascertained that MAOB was the target gene of miR-522. Rescue experiments disclosed that the relationship was indeed existed between miR-522 and MAOB.…”

Section: Discussionmentioning

confidence: 99%

“…6,20,21 In addition, the vital effects of MAOB in Alzheimer's disease and Parkinson's disease have also been elaborated. 22,23 In current study, we first described that miR-522 was overexpressed in endometrial cancer tissues and cell lines and exerts promoting functions in proliferation, migration, and invasion of endometrial cancer cell. Furthermore, the poor prognosis was induced by the higher expression level of miR-522.…”

Section: Introductionmentioning

confidence: 91%

“…It has been previously reported that the activity of mitochondria is related with the G/A polymorphism in intron 13 of the MAOB gene . In addition, the vital effects of MAOB in Alzheimer's disease and Parkinson's disease have also been elaborated …”

Section: Introductionmentioning

confidence: 98%

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miR‐522 facilitates the prosperities of endometrial carcinoma cells by directly binding to monoamine oxidase B

Zhang

Han

Zhang

et al. 2019

The Kaohsiung J of Med Scie

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It is well known that microRNAs (miRNAs) are crucial regulatory factors in tumorigenesis, as tumor suppressors or cancer‐promoting factors. However, the study of endometrial carcinoma relevance in miR‐522 is rare, indicating an undefined molecular mechanism for its role. Therefore, we performed this study to examine the role of miR‐522 on the biological behaviors of endometrial carcinoma. In this work, we found that miR‐522 was highly expressed in endometrial carcinoma and negatively regulated monoamine oxidase B (MAOB) expression. They also have the opposite effect on prognosis of endometrial carcinoma patients. More importantly, miR‐522 could decreased MAOB expression by binding to MAOB with a putative site, thereby promoting cell proliferation, migration, and invasion through in vitro functional analyses, including MTT assay, wound‐healing and transwell invasion experiments. Upregulation of MAOB rescued the impacts of miR‐522 mimic on cell behaviors. In conclusion, our observations demonstrated that miR‐522 accelerated the progression of endometrial carcinoma by inhibiting MAOB, which might lead to a novel therapeutic therapy for endometrial carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

miR‐522 facilitates the prosperities of endometrial carcinoma cells by directly binding to monoamine oxidase B

Zhang

Han

Zhang

et al. 2019

The Kaohsiung J of Med Scie

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“…Neurobehavioral sensory tests (mechanical and thermal hyperalgesia, and tail flick tests) were evaluated for all experimental animals as previously described [26]. Mechanical hyperalgesia was measured using Analgesia Meter (Ugo-Basile, Linton instrumentation, Italy).…”

Section: Methodsmentioning

confidence: 99%

Neurotherapeutic effects of Ginkgo biloba extract and its terpene trilactone, ginkgolide B, on sciatic crush injury model: A new evidence

2019

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Ginkgo biloba leaves extract (GBE) was subjected to neuroprotective-guided fractionation to produce eleven fractions with different polarities and constituents. The intermediate polar fraction was shown to be terpene trilactones-enriched fraction (TEGBE). Out of this fraction, pure ginkgolide B (G-B) was further purified and identified based on its spectral data. The effects of GBE and TEGBE were evaluated in comparison to that of G-B in the crush sciatic nerve injury rat model. To evaluate the neuroprotective effects, sixty Wistar male rats were randomly allocated into 6 groups: naive, sham, crush + normal saline, and three treatment groups; crush + GBE, crush + TEGBE, and crush + G-B. Treatments were given one hour following injury, and once daily for 14 days. Neurobehavioral tests, histomorphological examinations, and immunohistochemical analysis of the sciatic nerve and the spinal cord were performed at weeks 3 and 6 post-injury. GBE, TEGBE and G-B were shown to enhance the functional and sensory behavioral parameters and to protect the histological and the ultrastructural elements in the sciatic nerve. Additionally, all treatments prevented spinal cord neurons from further deterioration. It was shown that G-B has the most significant potential effects among all treatments with values that were nearly comparable to those of sham and naive groups.

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Carnosine improves functional recovery and structural regeneration after sciatic nerve crush injury in rats

et al. 2018

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Monoamine oxidase-B inhibitor protects degenerating spinal neurons, enhances nerve regeneration and functional recovery in sciatic nerve crush injury model

Cited by 10 publications

References 75 publications

miR‐522 facilitates the prosperities of endometrial carcinoma cells by directly binding to monoamine oxidase B

miR‐522 facilitates the prosperities of endometrial carcinoma cells by directly binding to monoamine oxidase B

Neurotherapeutic effects of Ginkgo biloba extract and its terpene trilactone, ginkgolide B, on sciatic crush injury model: A new evidence

Carnosine improves functional recovery and structural regeneration after sciatic nerve crush injury in rats

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