Monkeypox in pregnancy: update on current outbreak

Khalil, Asma; Samara, Athina; O’Brien, Pat; Coutinho, Conrado Milani; Duarte, Geraldo; Quintana, Silvana Maria; Ladhani, Shamez

doi:10.1016/s1473-3099(22)00612-0

Cited by 20 publications

(17 citation statements)

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“… 81 At least 12 pregnant women have been infected during the 2022 outbreak, but vertical transmission was not observed in any case. 82 This difference might be partly related to the greater invasiveness of clade 1 than clade 2.…”

Section: Transmissionmentioning

confidence: 99%

“… 13 , 14 However, among the few children, adolescents, and pregnant women infected during the 2022 outbreak, there have been no severe cases or adverse neonatal outcomes. 82 , 91 The risk of severe disease in people with HIV appears to vary depending on their immunological status. Reports from individuals admitted to hospital during the 2017–18 outbreak in Nigeria indicate that people with advanced and uncontrolled HIV infection might be at higher risk for severe, extensive, or prolonged monkeypox disease after infection.…”

Section: Population At Riskmentioning

confidence: 99%

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Monkeypox

Mitjà¹,

Ogoina²,

Titanji³

et al. 2023

The Lancet

186

164

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Section: Transmissionmentioning

confidence: 99%

Section: Population At Riskmentioning

confidence: 99%

Monkeypox

Mitjà¹,

Ogoina²,

Titanji³

et al. 2023

The Lancet

186

164

View full text Add to dashboard Cite

“…However, cesarean delivery is recommended if the mother presents with genital or anorectal lesions and/or PCR tests are not available. General anesthesia and neuraxial anesthesia considerations are necessary to be considered if oropharyngeal or cutaneous lesions near the insertion site, respectively, do exist [ 36 , 44 , 45 , 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…Based on existing studies of the safety/effectiveness of immunoglobulins administered, in pregnancy an antibody cocktail purified from the blood of individuals previously immunized with the smallpox vaccine can be proposed. Lastly, the limited data available on safety or efficacy of the smallpox vaccine, MVA-BN hinder evidence-based care for this high-risk group [ 45 , 46 , 47 ] (see details in next section).…”

Section: Resultsmentioning

confidence: 99%

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Monkeypox Infection 2022: An Updated Narrative Review Focusing on the Neonatal and Pediatric Population

Gaeta

Franci

et al. 2022

Children

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Monkeypox disease has been endemic in sub-Saharan Africa for decades, attracting remarkable attention only i23n 2022 through the occurrence of a multi-country outbreak. The latter has raised serious public health concerns and is considered a public health emergency by the World Health Organization. Although the disease is usually self-limiting, it can cause severe illness in individuals with compromised immune systems, in children, and/or the pregnant woman–fetus dyad. Patients generally present with fever, lymphadenopathy, and a vesicular rash suggestive of mild smallpox. Serious eye, lung and brain complications, and sepsis can occur. However, cases with subtler clinical presentations have been reported in the recent outbreak. A supportive care system is usually sufficient; otherwise, treatment options are needed in patients who are immunocompromised or with comorbidities. A replication-deficient modified and a live infectious vaccinia virus vaccine can be used both before and after exposure. Due to the persistent spread of monkeypox, it is necessary to focus on the pediatric population, pregnant women, and newborns, who represent fragile contagion groups. Here we assess and summarize the available up-to-date information, focusing on available therapeutic options, with insights into social and school management, breastfeeding, and prevention that will be useful for the scientific community and in particular neonatal and pediatric health professionals.

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A review of monkeypox infection during pregnancy

Farah

Nasr

Ramadan

et al. 2022

Intl J Gynecology & Obste

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The present study aimed to review monkeypox infection during pregnancy: its epidemiology and etiology, transmission, clinical manifestations and complications, diagnosis, management, antenatal testing and delivery, prevention, awareness, and recommendations. Monkeypox can spread via vertical transmission. The usual clinical symptoms include fever, rash (vesicles, crust), new genital lesions, or sore throat. It is only recommended to use cidofovir in pregnant patients when they are severely infected with monkeypox. All woman who are at high risk of exposure for monkeypox need to be vaccinated with the smallpox vaccine regardless of their pregnancy status. Monitoring includes regular non‐stress test monitoring in addition to ultrasound performed at various stages of pregnancy. High index of suspicion, informed physicians, reporting of cases, and support of research are all needed for the management of monkeypox infection during pregnancy.

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Monkeypox in pregnancy: update on current outbreak

Cited by 20 publications

References 0 publications

Monkeypox

Monkeypox

Monkeypox Infection 2022: An Updated Narrative Review Focusing on the Neonatal and Pediatric Population

A review of monkeypox infection during pregnancy

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