Monitoring Dopamine in the Mesocorticolimbic and Nigrostriatal Systems by Microdialysis: Relevance for Mood Disorders and Parkinson's Disease

Giovanni, Giuseppe Di; Pierucci, Massimo; Matteo, Vincenzo Di

doi:10.1002/9781118011294.ch4

Cited by 1 publication

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“…The first target for application of MD was the central nervous system (CNS) of experimental animals. The main goal of these studies was to investigate brain function and changes in levels of endogenous compounds such as neurotransmitters or metabolites [6] . Nevertheless, in CNS studies, reverse MD (retrodialysis) has also been used extensively to investigate the effects of diverse pharmacological and toxicological agents, such as antidepressants, antipsychotics, antiparkinson molecules, hallucinogens, drugs of abuse, and experimental drugs, on local effects on neurotransmission at various central nuclei.…”

Section: Target Organsmentioning

confidence: 99%

Microdialysis Techniques In Pharmacokinetic and Biomarker Studies Past, Present and Future Directions A Review

Erdő¹

2015

Clin Exp Pharmacol

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Microdialysis (MD) techniques were first applied in the early 1960s. The fields of their application comprised probe implantation into the central nervous system (CNS) at the beginning, and then expanded to almost every organ summarized in this article. After its early experimental applications MD became an important tool in the human pharmacokinetic/pharmacodynamic (PK/PD) studies as well. This monitoring technique is capable for investigation of local unbound concentrations of both endogenous and exogenous compounds in the interstitial fluid. The review shows examples for the role of MD in pharmacodynamic studies and for its use in tissue distribution and drug-transporter interaction studies. Determination of test substances in the dialysate samples needs sensitive bioanalytical methods. The main analytical techniques coupled with MD are summarized under the subtitle "Target molecules". New trend in the application of MD is the determination of large molecular entities in the extracellular fluid of target tissues. This approach greatly helps in the discovery of new pathophysiological pathways and identification of new therapeutic intervention strategies for several disorders. Finally, the article gives an overview on the complementary techniques (positron emission tomography, magnetic resonance spectroscopy and open flow microperfusion), and presents their advantages and limitations versus to in vivo MD. In summary, MD techniques have a wide variety of the fields of application. There are several new approaches using this methodology. The relatively low price and the importance of the information gained on the pharmacologically active form of the test articles at the site of interest guarantees a significant position of this technique in the preclinical and clinical research.

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Section: Target Organsmentioning

confidence: 99%

Microdialysis Techniques In Pharmacokinetic and Biomarker Studies Past, Present and Future Directions A Review

Erdő¹

2015

Clin Exp Pharmacol

View full text Add to dashboard Cite

show abstract

Monitoring Dopamine in the Mesocorticolimbic and Nigrostriatal Systems by Microdialysis: Relevance for Mood Disorders and Parkinson's Disease

Cited by 1 publication

References 353 publications

Microdialysis Techniques In Pharmacokinetic and Biomarker Studies Past, Present and Future Directions A Review

Microdialysis Techniques In Pharmacokinetic and Biomarker Studies Past, Present and Future Directions A Review

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