Monitoring changes and predicting loss of ambulation in Duchenne muscular dystrophy with the Motor Function Measure

Vuillerot, Carole; Girardot, F.; Payán, C.; Fermanian, Jacques; Iwaz, Jean; Lattre, Capucine de; Bérard, C.

doi:10.1111/j.1469-8749.2009.03316.x

Cited by 99 publications

(132 citation statements)

References 15 publications

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“…(15,16) The GMFM assesses the gross motor abilities of children with CP and MFM of children with neuromuscular diseases. The scores of both scales were transformed into a percentage of the maximum score, and these percentages were analyzed together as a representation of motor function.…”

Section: Biochemical Measurementsmentioning

confidence: 99%

High-frequency, low-intensity vibrations increase bone mass and muscle strength in upper limbs, improving autonomy in disabled children

Reyes¹,

Hernández²,

Holmgren³

et al. 2011

Journal of Bone and Mineral Research

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Disuse osteoporosis in children is a progressive disease that can affect quality of life. High-frequency, low-magnitude vibration (HFLMV) acts as an anabolic signal for bone and muscle. We undertook a prospective, randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of regional HFLMV in disabled children. Sixty-five children 6 to 9 year of age were randomized into three groups: placebo, 60 Hz, and 90 Hz. In the two active groups, a 0.3-g mechanical vibration was delivered to the radii and femurs for 5 minutes each day. After 6 months, the main endpoint was bone mineral density (BMD) at the ultradistal radius (UDR), 33% radii (33%R), and femoral necks (FN). Secondary endpoints were area and bone mineral content (BMC) at the UDR, 33%R, and FN; grip force of the upper and lower limbs; motor function; and PedsQL evaluation. An intention-to-treat analysis was used. Fifty-seven children (88%) completed the protocol. A significant increase was observed in the 60-Hz group relative to the other groups in BMD at the UDR ( p ¼ .011), in grip force of the upper limbs ( p ¼ .035), and in the ''daily activities item'' ( p ¼ .035). A mixed model to evaluate the response to intervention showed a stronger effect of 60 Hz on patients with cerebral palsy on the UDR and that between-subject variability significantly affected the response. There were no reported side effects of the intervention. This work provides evidence that regional HFLMV is an effective and safe strategy to improve bone mass, muscle strength, and possibly independence in children with motor disabilities. ß

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Section: Biochemical Measurementsmentioning

confidence: 99%

High-frequency, low-intensity vibrations increase bone mass and muscle strength in upper limbs, improving autonomy in disabled children

Reyes¹,

Hernández²,

Holmgren³

et al. 2011

Journal of Bone and Mineral Research

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show abstract

“…Studies have shown the relevance of motor function follow up to monitor DMD accurately 2,3,4 . Global motor scales should be complemented by functional tasks assessment because, despite the continued decline in muscle strength, children with DMD continue to perform the activities using compensatory movements 5,6 . The analysis of compensatory movements employed during functional activities shows the changes in muscular synergies.…”

mentioning

confidence: 99%

How often should sitting and rising from a chair be evaluated in patients with Duchenne muscular dystrophy?

Hukuda

Caromano

Escórcio

et al. 2017

Arq. Neuro-Psiquiatr.

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Objective: To determine how often sitting/rising from a chair should be assessed in Duchenne muscular dystrophy (DMD) patients to avoid redundant/missing data. Methods: Sitting/rising from a chair was evaluated in 26 DMD children (5-12 yrs), in three-month intervals, over twelve months, with the Functional Evaluation Scale (domain sitting/rising from a chair). Scores were compared by effect sizes (ES) and standardized response means (SRM) (responsiveness analysis). Results: Sit-to-stand showed low-to-moderate responsiveness in three-month intervals

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“…For instance, Vuillerot et al 30 showed that the MFM was useful to detect mobility loss and functional dependence increase. It predicted gait loss within a year, when Dimension 1 was 40% or lower 30 . Conversely, Bakker et al 26 showed that MRC provided good references for DMD prognosis.…”

Section: Bartels Et Almentioning

confidence: 99%

Relationship between muscle strength and motor function in Duchenne muscular dystrophy

Nunes

Hukuda

Fávero

et al. 2016

Arq. Neuro-Psiquiatr.

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Measuring muscle strength and motor function is part of Duchenne muscular dystrophy (DMD) assessment. However, the relationship between these variables is controversial. Objective To investigate the relationship between muscle strength and motor function and between these variables and age. Method Muscle strength was measured by Medical Research Council (MRC) scale and motor function, by Motor Function Measure (MFM), in 40 non-ambulatory patients. Spearman tests investigated the relationships between muscle strength, motor function and age. Results Total MRC and MFM scores were strongly related to each other (r = 0.94; p < 0.001), but not to age (r = -0.19, r = -0.31, respectively; p > 0.05). Strong and moderate relationships between partial muscle strength and motor function scores were found. Higher correlation coefficients were found between total scores and Dimensions 2 (axial/ proximal control) and 3 (distal control) of MFM. Conclusion Muscle strength and motor function are strongly correlated and seem to decrease proportionally in DMD.

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Monitoring changes and predicting loss of ambulation in Duchenne muscular dystrophy with the Motor Function Measure

Cited by 99 publications

References 15 publications

High-frequency, low-intensity vibrations increase bone mass and muscle strength in upper limbs, improving autonomy in disabled children

High-frequency, low-intensity vibrations increase bone mass and muscle strength in upper limbs, improving autonomy in disabled children

How often should sitting and rising from a chair be evaluated in patients with Duchenne muscular dystrophy?

Relationship between muscle strength and motor function in Duchenne muscular dystrophy

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