MON-P025: Association between Heart Rate Variability Measures and Energy Homeostasis in Patients with Vegetative Status: A Prospective Clinical Cohort Pilot Study

Kiryachkov, Yuri Y.; Shelkunova, I.; Kolesov, Dmitry L.; Danilec, V.

doi:10.1016/s0261-5614(17)31058-0

Cited by 1 publication

(1 citation statement)

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“…Autonomic function, ANS-mediated responsiveness and the ANS-CNS interaction qualify as possible independent indicators for clinical functional assessment, diagnosis and prognosis in DoC (King et al, 2009; Ryan et al, 2011; Sannita, 2015; Riganello, 2016). In a reversed perspective, research on the residual modular functions in DoC can provide unique information about brain mechanisms/functions and ANS-CNS interplay that can be investigated in these patients under experimental conditions that are rigorously controlled (Monti, 2012; Riganello et al, 2012b; Sannita, 2014; Shen et al, 2016; Chennu et al, 2017; Kiryachkov et al, 2017).…”

Section: Comment and Perspectivesmentioning

confidence: 99%

Measures of CNS-Autonomic Interaction and Responsiveness in Disorder of Consciousness

Riganello

Larroque²,

Perri

et al. 2019

Front. Neurosci.

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Neuroimaging studies have demonstrated functional interactions between autonomic (ANS) and brain (CNS) structures involved in higher brain functions, including attention and conscious processes. These interactions have been described by the Central Autonomic Network (CAN), a concept model based on the brain-heart two-way integrated interaction. Heart rate variability (HRV) measures proved reliable as non-invasive descriptors of the ANS-CNS function setup and are thought to reflect higher brain functions. Autonomic function, ANS-mediated responsiveness and the ANS-CNS interaction qualify as possible independent indicators for clinical functional assessment and prognosis in Disorders of Consciousness (DoC). HRV has proved helpful to investigate residual responsiveness in DoC and predict clinical recovery. Variability due to internal (e.g., homeostatic and circadian processes) and environmental factors remains a key independent variable and systematic research with this regard is warranted. The interest in bidirectional ANS-CNS interactions in a variety of physiopathological conditions is growing, however, these interactions have not been extensively investigated in DoC. In this brief review we illustrate the potentiality of brain-heart investigation by means of HRV analysis in assessing patients with DoC. The authors’ opinion is that this easy, inexpensive and non-invasive approach may provide useful information in the clinical assessment of this challenging patient population.

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