Molybdenum derived from nanomaterials incorporates into molybdenum enzymes and affects their activities in vivo

Cao, Mingjing; Cai, Rong; Zhao, Lina; Guo, Mengyu; Wang, Liming; Wang, Yucai; Zhang, Lili; Wang, Xiaofeng; Yao, Haodong; Xie, Chunyu; Cong, Yalin; Guan, Yong; Tao, Xia-Yu; Wang, Yaling; Xu, Shaoxin; Liu, Ying; Zhao, Yuliang; Chen, Chunying

doi:10.1038/s41565-021-00856-w

Cited by 181 publications

(169 citation statements)

References 51 publications

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“…Additionally, beginning on Day 3, Mo shown a decrease in the spleen and an increase in the liver (Figure S10), which may result from the degradation of MPTF and their further translocating via the splenic vein to the hepatic portal vein and nally being utilized in molybdenum enzymes, consistent with the previous work [51]. Likewise, the excretion of MPTF in vivo after injection for one week was explored (Figure S11).…”

Section: Systemic Toxicity Biodistribution and Biodegradation In Vivosupporting

confidence: 78%

Safe and Efficient Molybdenum Disulfide Platform for Cooperative Imaging-Guided Photothermal-Selective Chemotherapy: A Preclinical Study

Kong

et al. 2021

Preprint

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Background The striking imbalance between the ever-increasing amount of nanomedicines and low clinical translation of products has become the focus of intense debate. For clinical translation, the critical issue is to select the appropriate agents and combination regimen for targeted diseases, not to prepare increasingly complex nanoplatforms. Methods Herein, a safe and efficient platform, α-tocopheryl succinate (α-TOS) married 2D molybdenum disulfide, was devised by a facile method and applied for cooperative imaging-guided photothermal-selective chemotherapy of ovarian carcinoma. Results The photothermal efficiency (65.3%) of the platform under safe near-infrared irradiation is much higher than that of other photothermal materials reported elsewhere. Moreover, the covalently linked α-TOS renders platform with selective chemotherapy for cancer cells. Remarkably, with these excellent properties, the platform can be used to completely eliminate the solid tumor by safe photothermal therapy, and then kill the residual cancer cells by selective chemotherapy to prevent tumor recurrence. More significantly, barely side effects occurred in the whole treatment process. The excellent efficacy and safety benefits in vivo lead to the prominent survival rate of 100% over 91 days. Conclusion Overall, the safe and efficient platform might be a candidate of clinical nanomedicines for multimode theranostics. This study demonstrates an innovative thought in precise nanomedicine regarding the design of next generation of cancer theranostic protocol for potential clinical practice.

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Section: Systemic Toxicity Biodistribution and Biodegradation In Vivosupporting

confidence: 78%

Safe and Efficient Molybdenum Disulfide Platform for Cooperative Imaging-Guided Photothermal-Selective Chemotherapy: A Preclinical Study

Kong

et al. 2021

Preprint

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“…While for MoS 2 ‐Agg the obvious explanation is the phagocytic activity of KUP5 cells, the in vivo study by Cao et al. also showed the sequestration of protein‐coated MoS 2 @HSA nanocomplexes by KCs and the uptake of by KCs was around 5.4‐ to 9.2‐fold higher than that by hepatocytes, [ 69 ] however, this does not explain the lack of cytotoxicity of dissolvable MoS 2 ‐PF in these cells. Another explanation is the different sensitivity to nanomaterial toxicity among KCs, LSECs, and hepatocytes.…”

Section: Discussionmentioning

confidence: 97%

Dissolution of 2D Molybdenum Disulfide Generates Differential Toxicity among Liver Cell Types Compared to Non‐Toxic 2D Boron Nitride Effects

Guiney

Downing

et al. 2021

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2D boron nitride (BN) and molybdenum disulfide (MoS2) materials are increasingly being used for applications due to novel chemical, electronic, and optical properties. Although generally considered biocompatible, recent data have shown that BN and MoS2 could potentially be hazardous under some biological conditions, for example, during, biodistribution of drug carriers or imaging agents to the liver. However, the effects of these 2D materials on liver cells such as Kupffer cells (KCs), liver sinusoidal endothelial cells, and hepatocytes, are unknown. Here, the toxicity of BN and MoS2, dispersed in Pluronic F87 (designated BN‐PF and MoS2‐PF) is compared with aggregated forms of these materials (BN‐Agg and MoS2‐Agg) in liver cells. MoS2 induces dose‐dependent cytotoxicity in KCs, but not other cell types, while the BN derivatives are non‐toxic. The effect of MoS2 could be ascribed to nanosheet dissolution and the release of hexavalent Mo, capable of inducing mitochondrial reactive oxygen species generation and caspases 3/7‐mediated apoptosis in KUP5 cells. In addition, the phagocytosis of MoS2‐Agg triggers an independent response pathway involving lysosomal damage, NLRP3 inflammasome activation, caspase‐1 activation, IL‐1β, and IL‐18 production. These findings demonstrate the importance of Mo release and the state of dispersion of MoS2 in impacting KC viability.

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“…The results suggested that the liver was the main organ where Mo accumulated, which was consistent with previous reports. [40] Although Mo ions were distributed in the liver, kidneys, spleen, lungs, heart, and brain, with primary occurrence in the kidneys, no noticeable signs of pathological tissue abnormalities were observed in any of the major organs examined (Figure S30, Supporting Information). In addition, the biotransformation of MoS 2 leads to the incorporation of molybdenum into molybdenum enzymes, which increases their specific activities in the liver, and MoS 2 has no effect on cytokines involved in the liver.…”

Section: Prevention Of Neurotoxicity In Vitro and Vivomentioning

confidence: 99%

“…In addition, the biotransformation of MoS 2 leads to the incorporation of molybdenum into molybdenum enzymes, which increases their specific activities in the liver, and MoS 2 has no effect on cytokines involved in the liver. [40] The interaction between 1T-MoS 2 nanosheets and PC12 cells was further measured using FTIR, as shown in Figure S31 in the Supporting Information. The 1T-MoS 2 nanosheets mainly interacted with polysaccharides and proteins of PC12 cells according to the integration of FTIR.…”

Section: Prevention Of Neurotoxicity In Vitro and Vivomentioning

confidence: 99%

Bionanoscale Recognition Underlies Cell Fate and Therapy

Sun

Deng

et al. 2021

Adv Healthcare Materials

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Understanding the bionanoscale recognition of nanostructured architectures is critical to the design and application of nanomaterials, but the related information is not well understood. In this study, it is found that bionanoscale recognition underlies cell fate and therapy. For example, 1T phase (octahedral coordination) monolayer MoS 2 exhibits a markedly stronger affinity for fibronectin than the 2H structure (triangular prism coordination) and promotes cell spreading and differentiation. The van der Waals energy and increased turn components contribute to the high adhesion of fibronectin onto the 1T-MoS 2 structure. 1T-MoS 2 exhibits a significantly stronger affinity (K D , 6.59 × 10 −7 m) for liposomes than 2H-MoS 2 (1.21 × 10 −6 m) due to strong hydrophobic interactions. The existence of octahedrally coordinated atomic structures that improve cell viability by enhancing the neurite length is first proven by random forest and structural equation models. Consequently, octahedral coordination disaggregates 𝜶-synuclein (e.g., by decreasing 𝜷-sheets and increasing coil structures) and protects cells and hosts against Parkinson's disease. As a proof-of-principle demonstration, these findings indicate that bionanoscale recognition underlies the design of biomaterials and cell therapeutics.

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Molybdenum derived from nanomaterials incorporates into molybdenum enzymes and affects their activities in vivo

Cited by 181 publications

References 51 publications

Safe and Efficient Molybdenum Disulfide Platform for Cooperative Imaging-Guided Photothermal-Selective Chemotherapy: A Preclinical Study

Safe and Efficient Molybdenum Disulfide Platform for Cooperative Imaging-Guided Photothermal-Selective Chemotherapy: A Preclinical Study

Dissolution of 2D Molybdenum Disulfide Generates Differential Toxicity among Liver Cell Types Compared to Non‐Toxic 2D Boron Nitride Effects

Bionanoscale Recognition Underlies Cell Fate and Therapy

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