Molnupiravir: First Approval

Syed, Yahiya Y.

doi:10.1007/s40265-022-01684-5

Cited by 69 publications

(73 citation statements)

References 28 publications

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“… 310 , 311 Molnupiravir has been approved by FDA for clinical use as the first oral drug treating SARS-CoV-2, and it displayed broad efficacy against multiple RNA viruses. 270 , 294 , 312 Studies found that it could effectively inhibit the infection of both SARS-CoV-2 ancestral strain and Omicron variant in vitro (EC 50 3.57–4.15 μM—WT and 1.86–1.95 μM—Omicron). 5 , 263…”

Section: Molecular Characteristics Of Sequence and The Encoded Protei...mentioning

confidence: 99%

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

Sun

Xie

et al. 2022

Sig Transduct Target Ther

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The persistent COVID-19 pandemic since 2020 has brought an enormous public health burden to the global society and is accompanied by various evolution of the virus genome. The consistently emerging SARS-CoV-2 variants harboring critical mutations impact the molecular characteristics of viral proteins and display heterogeneous behaviors in immune evasion, transmissibility, and the clinical manifestation during infection, which differ each strain and endow them with distinguished features during populational spread. Several SARS-CoV-2 variants, identified as Variants of Concern (VOC) by the World Health Organization, challenged global efforts on COVID-19 control due to the rapid worldwide spread and enhanced immune evasion from current antibodies and vaccines. Moreover, the recent Omicron variant even exacerbated the global anxiety in the continuous pandemic. Its significant evasion from current medical treatment and disease control even highlights the necessity of combinatory investigation of the mutational pattern and influence of the mutations on viral dynamics against populational immunity, which would greatly facilitate drug and vaccine development and benefit the global public health policymaking. Hence in this review, we summarized the molecular characteristics, immune evasion, and impacts of the SARS-CoV-2 variants and focused on the parallel comparison of different variants in mutational profile, transmissibility and tropism alteration, treatment effectiveness, and clinical manifestations, in order to provide a comprehensive landscape for SARS-CoV-2 variant research.

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Section: Molecular Characteristics Of Sequence and The Encoded Protei...mentioning

confidence: 99%

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

Sun

Xie

et al. 2022

Sig Transduct Target Ther

View full text Add to dashboard Cite

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“…Introduction Molnupiravir is a RNA replication inhibitor and an antiviral drug receiving first approval in UK for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV-2) by 4th of November, 2021. It acts similar to Remdesivir [1,2]. According to Phase 2 and Phase 3 clinical study results, it was generally well tolerated and less adverse events were reported which were found to be not dose related [1,3].…”

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confidence: 90%

A Validated High-Pressure Liquid Chromatography (HPLC) Method for Molnupiravir

Camlik

Beyazaslan²,

Kara³

et al. 2022

MRAJ

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Molnupiravir is an approved antiviral drug that inhibits RNA replication of viruses. It is approved recently (November 2021) for the treatment of infectious diseases caused by SARS-CoV-2. However, it is reported that Molnupiravir is a nucleoside analogue and shown that nucleoside analogues are reagents that resemble the structure of natural nucleosides. It is widely applied in antiviral and anticancer therapy. Therefore, there is a general need appeared for an efficient, fast, simple, and validated analytical assay method for the quantification of this new product in any samples. We report here that an HPLC method was developed, optimized, and validated for molnupravir. The developed method was found to be easy to apply, cheap, and time-saving. Isocratic elution with 10mM Phosphate Buffer pH:7 / Acetonitrile mixture (80:20) with a Phenomenex C18 column was performed and a photodiode array detector was used for the detection. The total time for the analysis was only 10 minutes. The method was found to be selective, linear, accurate, reproducible, and robust. This proposed method can be easily adapted for molnupravir analyses in pharmaceutical products or in any other biological or non-biological samples.

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“…Table 2 shows the scientific aspect of the history of infectious diseases [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ], and Table 3 shows infectious diseases studied using molecular techniques, including metagenomics. Different reviews as well as two important books explore this field [ 81 , 82 , 83 , 84 , 85 , 86 ].…”

Section: History Of “Plagues”mentioning

confidence: 99%

Preventive Measures against Pandemics from the Beginning of Civilization to Nowadays—How Everything Has Remained the Same over the Millennia

Vitiello

Ilari

Sansone

et al. 2022

JCM

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As of 27 March 2022, the β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 487 million individuals worldwide, causing more than 6.14 million deaths. SARS-CoV-2 spreads through close contact, causing the coronavirus disease 2019 (COVID-19); thus, emergency lockdowns have been implemented worldwide to avoid its spread. COVID-19 is not the first infectious disease that humankind has had to face during its history. Indeed, humans have recurrently been threatened by several emerging pathogens that killed a substantial fraction of the population. Historical sources document that as early as between the 10th and the 6th centuries BCE, the authorities prescribed physical–social isolation, physical distancing, and quarantine of the infected subjects until the end of the disease, measures that strongly resemble containment measures taken nowadays. In this review, we show a historical and literary overview of different epidemic diseases and how the recommendations in the pre-vaccine era were, and still are, effective in containing the contagion.

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Molnupiravir: First Approval

Cited by 69 publications

References 28 publications

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

A Validated High-Pressure Liquid Chromatography (HPLC) Method for Molnupiravir

Preventive Measures against Pandemics from the Beginning of Civilization to Nowadays—How Everything Has Remained the Same over the Millennia

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