Molecularly Imprinted Polymers for the Removal of Antide-Pressants from Contaminated Wastewater

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants regularly detected in the environment. This indicates that the existing wastewater treatment techniques are not successfully removing them beforehand. This study investigated the potential of molecularly imprinted polymers (MIPs) to serve as sorbents for removal of SSRIs in water treatment. Sertraline was chosen as the template for imprinting. We optimized the composition of MIPs in order to obtain materials with highest capacity, affinity, and selectivity for sertraline. We report the maximum capacity of MIP for sertraline in water at 72.6 mg g−1, and the maximum imprinting factor at 3.7. The MIPs were cross-reactive towards other SSRIs and the metabolite norsertraline. They showed a stable performance in wastewater-relevant pH range between 6 and 8, and were reusable after a short washing cycle. Despite having a smaller surface area between 27.4 and 193.8 m2·g−1, as compared to that of the activated carbon at 1400 m2·g−1, their sorption capabilities in wastewaters were generally superior. The MIPs with higher surface area and pore volume that formed more non-specific interactions with the targets considerably contributed to the overall removal efficiency, which made them better suited for use in wastewater treatment.

Application of Molecularly Imprinted Polymers in the Analysis of Waters and Wastewaters

“…High performance liquid chromatograph coupled with a diode array detector (HPLC-DAD) was used for the different detections. Despite the small surface area of the synthesized polymers that ranged between 27.4 and 193.8 m 2 g −1 , as compared to that of the activated carbon at 1400 m 2 g −1 , their sorption capabilities in wastewaters were generally superior [185].…”

Remediation of pharmaceuticals from contaminated water by molecularly imprinted polymers: a review

“…In aquatic organisms, they cause changes in growth processes, and feeding and survivorship behavior (Sehonova et al 2019 ; Stoczynski and van den Hurk 2020 ). Recently, a molecularly imprinted polymer based on methacrylic acid as functional monomers and sertraline as a template has been used for removal of not only targeted template but for the whole class of selective serotonin reuptake inhibitors has been reported by Gornik et al ( 2021 ); maximum imprinting factor was found to be 3.7, and the maximum capacity for sertraline was estimated at 72.6 mg g −1 . The molecularly imprinted polymers can form more non-specific interactions with the targets due to their high surface area and pore volume, thus improving the overall removal efficiency in wastewater treatment.…”

Pengaruh Konsentrasi Kloramfenikol Terhadap Adsorpsi Polimer Cetak Molekul Dengan Metode Presipitasi

“…Selanjutnya MIP dicuci dengan aquabidest, metanol, asetonitril. Pencucian menggunakan air untuk menghilangkan residu asam asetat karena residu asam ini dapat mempengaruhi pada proses rebinding selanjutnya [37] [38]. Metanol digunakan untuk menarik CAP lebih banyak pada MIP.…”