Molecularly imprinted layer-coated silica nanoparticles for selective solid-phase extraction of bisphenol A from chemical cleansing and cosmetics samples
“…It has been demonstrated that the untargeted compounds can be selectively washed off from the multi-template MIP surface due to their weaker non-specific interactions with the polymer [31]. Contrarily, some researchers have indicated that the use of a dummy template during polymerization increased the selectivity of the final MIPs that target more that target one compound [39,40].…”
In this chapter, the synthetic procedures for molecularly imprinted polymers (MIPs) for pharmaceutical compounds are discussed. Regardless of its limitations, such as production of irregular particles and loss of sample during processing (crushing and sieving), bulk polymerization has been widely used compared to say precipitation and suspension polymerization partly due to its simplicity in synthesis and robustness. A comparison of indomethacin removal from aqueous solution by MIP particles prepared using bulk polymerization to those obtained from suspension polymerization showed that the particles from the former exhibited higher adsorption capacity. Furthermore, the chapter explores the strengths and limitations relating the use of pharmaceutical compounds as uni-templates, multi-templates and dummy templates. Also, the analytical applications of MIPs are discussed in more details with particular focus on molecularly imprinted solid-phase extraction (MISPE) of pharmaceuticals from environmental samples. This application (MISPE) is currently the most exploited in literature as more pharmaceutical drugs find their way into environmental water bodies.
“…It has been demonstrated that the untargeted compounds can be selectively washed off from the multi-template MIP surface due to their weaker non-specific interactions with the polymer [31]. Contrarily, some researchers have indicated that the use of a dummy template during polymerization increased the selectivity of the final MIPs that target more that target one compound [39,40].…”
In this chapter, the synthetic procedures for molecularly imprinted polymers (MIPs) for pharmaceutical compounds are discussed. Regardless of its limitations, such as production of irregular particles and loss of sample during processing (crushing and sieving), bulk polymerization has been widely used compared to say precipitation and suspension polymerization partly due to its simplicity in synthesis and robustness. A comparison of indomethacin removal from aqueous solution by MIP particles prepared using bulk polymerization to those obtained from suspension polymerization showed that the particles from the former exhibited higher adsorption capacity. Furthermore, the chapter explores the strengths and limitations relating the use of pharmaceutical compounds as uni-templates, multi-templates and dummy templates. Also, the analytical applications of MIPs are discussed in more details with particular focus on molecularly imprinted solid-phase extraction (MISPE) of pharmaceuticals from environmental samples. This application (MISPE) is currently the most exploited in literature as more pharmaceutical drugs find their way into environmental water bodies.
“…Polymers which obtained these techniques, demonstrated much better access to binding cavities. These type of MIP were synthetized for selective recognition of BPA and tetrabromobisphenol A [41,43]. In situ polymerization techniques, whereas, found that the application for preparation of block co-polymer of 4-VP and EGDMA for BPA as a target molecule.…”
“…BPA, BPF, tetrabromobisphenol A, nonylophenols and their derivatives) from various environmental samples (river water, wastewaters, sewage sludge, sediments, soils), food, biological samples (serum, urine) and cosmetics [35,36,[40][41][42][43].…”
“…So, PTMS as functional monomer was employed for the imprinting and recognition process, possibly owing to the hydrophobic interaction and p-p interaction. The weakly polar acetonitrile was chosen as porogen because strongly polar solvents could counteract the formation of affinity bonds for templates, and acetic acid was chosen as the activator during the synthesis of molecularly imprinted sol-gel [35]. Thus, the imprinting process of PAHs regularly encoded the PAH shape of -SiO-SiO-SiO-conjoined to a functional phenyl group, and the specific cavity was formed after the imprinted molecule was eluted.…”
Section: Preparation and Characterization Of Mips For Pahsmentioning
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