Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma

Chae, Soo-Cheon; Song, Juhee; Heo, Jin-Chul; Lee, Yong-Chul; Kim, Jin-Wou; Chung, Hun‐Taeg

doi:10.1016/j.humimm.2003.09.011

Cited by 47 publications

(40 citation statements)

References 17 publications

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“…The four SNPs in the promoter region of TIM-1 gene have been previously investigated for their associations with the susceptibility to asthma and RA in a Korean and Chinese Han populations (Chae et al, 2003(Chae et al, , 2004b(Chae et al, , 2005Mou et al, 2010). To determine if these SNPs were also associated with susceptibility to RA in the Chinese Hui ethnicity, we analyzed the polymorphisms of the TIM-1 gene at the sites of -1637A>G, -1454G>A, -416G>C, and -232A>G in 118 RA patients and 118 non-arthritic controls from the Hui population.…”

Section: Resultsmentioning

confidence: 99%

“…The DNA was amplified for 35 cycles at 94°C for 30 s, 58-65°C for 45 s (Table 1), and 72°C for 45 s, with a final extension at 72°C for 5 min using the BioRad MyCycler Thermal Cycler (BioRad Laboratories, Hercules, CA, USA). Genotyping for -232A>G and -1637A>G SNPs in the TIM-1 gene was performed by SSP-PCR as previously reported with the primer sets listed in Table 1 (Chae et al, 2003). The PCR-RFLP analysis was employed for genotyping the -1454G>A and -416G>C polymorphic sites of the TIM-1 gene as described previously; the primer sets used for PCR and restriction endonucleases used for digestion are listed in Table 1 and Table 2 (Chae et al, 2005).…”

Section: Single Nucleotide Polymorphism Analysismentioning

confidence: 99%

“…T-cell immunoglobulin domain and mucin domain (TIM) proteins have been reported to be expressed on T cells and are involved in the regulation of T helper (Th) cells immune responses and allergic diseases such as asthma and rheumatoid arthritis (RA) (Chae et al, 2003(Chae et al, , 2004a(Chae et al, , 2005Gao et al, 2005;Mou et al, 2010). The TIM gene family consists of eight genes on mouse chromosome 11B1.1, and three genes lie on the human chromosome 5q33.2.…”

Section: Introductionmentioning

confidence: 99%

“…Selective expression on Th2 cells may suggest that TIM-1 is a candidate susceptibility gene associated with Th cell-mediated allergic and autoimmune diseases. Recent population studies have demonstrated that genetic variations in TIM-1 were associated with susceptibility to both allergic diseases and autoimmune diseases (Chae et al, 2003(Chae et al, , 2004a(Chae et al, ,b, 2005Gao et al, 2005;Wu et al, 2009a,b). Furthermore, previous polymorphism studies performed on the TIM-1 promoter region in a Korean population have identified a promoter polymorphism, -1637A>G, to be associated with susceptibility to RA in a Korean population (Chae et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population

Xu¹,

Yang²,

Liu³

et al. 2012

Genet. Mol. Res.

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Section: Resultsmentioning

confidence: 99%

Section: Single Nucleotide Polymorphism Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population

Xu¹,

Yang²,

Liu³

et al. 2012

Genet. Mol. Res.

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“…Certain human pathologies, in particular allergic diseases, are associated with TIM protein dysfunctions and polymorphisms (3)(4)(5). Viral infection has recently been linked to TIM proteins, with some TIMs acting as key factors for viral entry.…”

mentioning

confidence: 99%

TIM-family proteins inhibit HIV-1 release

Ablan

Miao

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance TIM-family proteins have been recently shown to promote viral entry into host cells. Unexpectedly, we discovered that human TIM-1, along with TIM-3 and TIM-4, potently inhibits HIV-1 release. We showed that TIM-1 is incorporated into HIV-1 virions and retains HIV-1 particles on the plasma membrane via phosphatidylserine (PS), a phospholipid that is exposed on the cellular plasma membrane and the viral envelope. Expression of TIM-1 inhibits HIV-1 replication in CD4 + T cells, and knockdown of TIM-3 in monocyte-derived macrophages enhances HIV-1 production. We extended this function of TIMs to other PS receptors, and demonstrated that they also inhibited release of additional viruses, including murine leukemia virus and Ebola virus. The novel role of TIMs in blocking viral release provides new insights into viral replication and AIDS pathogenesis.

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Genetic polymorphisms of rs9313422 G>C and rs41297579 G>A at the promoter of TIM‐1 gene contribute to the risk of community‐acquired pneumonia in children

Liu

2019

Clinical Laboratory Analysis

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Objective To investigate the association of genetic polymorphisms of rs9313422 G>C and rs41297579 G>A at the promoter of TIM‐1 gene with the risk of community‐acquired pneumonia (CAP) in children. Methods A total of 112 children with CAP were included as the case group. Another 120 healthy children were enrolled as the control group. Polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) was applied for the genotyping of rs9313422 G>C and rs41297579 G>A in the promoter region of TIM‐1. Results rs9313422 G>C was related to the risk of CAP in children under codominant model, dominant model, recessive model, and allele model. Besides, the A allele of rs41297579 G>A could increase the risk of CAP in children. Besides, the haplotype GA (rs9313422‐rs41297579) and GG reduced the risk of children CAP, while haplotype CA had an elevated risk. rs9313422 G>C and rs41297579 G>A polymorphisms were both associated with the severity of CAP in children, and the rs9313422 G>C was also related to the ICU admission rate. In addition, patients carried with the mutant homozygotes of rs9313422 G>C and rs41297579 G>A showed higher levels of white blood cell (WBC), procalcitonin (PCT), and C‐reactive protein (CRP) than the wild type and heterozygous genotypes carriers. Conclusion rs9313422 G>C and rs41297579 G>A polymorphisms in the promoter region of TIM‐1 could increase the risk of CAP in children and showed a relation with inflammatory responses and severity.

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Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma

Cited by 47 publications

References 17 publications

Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population

Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population

TIM-family proteins inhibit HIV-1 release

Genetic polymorphisms of rs9313422 G>C and rs41297579 G>A at the promoter of TIM‐1 gene contribute to the risk of community‐acquired pneumonia in children

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