Molecular recognition of melamine and cyanuric acid by C2-symmetric phenylalanine based supramolecular hydrogels

Mehwish, Nabila; Kousar, Ayesha; Dang-i, Auphedeous Yinme; Huang, Juexin; Dou, Xiaoqiu; Feng, Chuanliang

doi:10.1016/j.eurpolymj.2019.05.059

Cited by 9 publications

(3 citation statements)

References 37 publications

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“…To further govern the cell response, chiral molecules can be incorporated into the cryogel system by either co-assembly or a simple surface functionalization strategy. We are planning to investigate chirality-dependent cell adhesion and differentiation for creating bone tissue and regenerative therapies in the future [ 88 , 89 ]. According to CLSM micrographs ( Figure 9 b), fibroblasts adhered well to both scaffolds (BM, BM-PDA) while the spreading of fibroblasts was more obvious in the BM-PDA scaffolds.…”

Section: Resultsmentioning

confidence: 99%

Mussel-Inspired Surface Functionalization of Porous Albumin Cryogels Supporting Synergistic Antibacterial/Antioxidant Activity and Bone-Like Apatite Formation

Mehwish

Zaeem

et al. 2022

Gels

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A crucial method for adding new functions to current biomaterials for biomedical applications has been surface functionalization via molecular design. Mussel-inspired polydopamine (PDA) has generated much attention as a facile method for the functionalization of biomaterials because of its substantial independence in deposition, beneficial cell interactions, and significant responsiveness aimed at secondary functionalization. Because of their porous structure, the bovine serum albumin methacryloyl (BSAMA)-BM cryogels were functionalized with PDA (BM˗PDA), which may reproduce the architecture and biological purpose of the natural extracellular environment. Excellent antioxidative and antibacterial qualities, improved mineralization, and better cell responsiveness were all demonstrated by BM˗PDA. BM˗PDA scaffolds maintained their linked and uniform pores after functionalization, which can make it easier for nutrients to be transported during bone repair. As a result, hydroxyapatite (HA)-coated BM* and BM˗PDA* cryogels were created through successive mineralization with the goal of mineralized bone tissue repair. The heterogeneous nucleation and surface roughness contributed to rod-like apatite production in BM˗PDA* cryogels whereas BM* cryogels were made up of plate-like HA morphologies. Analysis results showed that after five cycles, the mineral contents were around 57% and the HA units remained equally dispersed on the surface of BM˗PDA* with a Ca/P ratio of 1.63. Other natural polymer-based cryogels can be coated using this general, rapid, and simple PDA coating technique and utilized as implants for bone tissue engineering. Future clinical uses of albumin cryogels for bone tissue engineering will advance as a result of additional in-vivo testing of such PDA-coated cryogels.

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Section: Resultsmentioning

confidence: 99%

Mussel-Inspired Surface Functionalization of Porous Albumin Cryogels Supporting Synergistic Antibacterial/Antioxidant Activity and Bone-Like Apatite Formation

Mehwish

Zaeem

et al. 2022

Gels

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“…Yet, there are only a few to no examples of the synthesis of C2‐symmetric conductive hydrogels based on NDI core. Moreover, progress has been made regarding C2‐symmetric hydrogels with various applications such as chirality modulation, [9] molecular recognitions, [10] morphology tuning, [11] antibacterial activities, [12] and cell culture [13] . However, there is a lack of research on C2‐ symmetric supramolecular conductive hydrogels.…”

Section: Introductionmentioning

confidence: 99%

NDI based C2‐symmetric Chiral Supramolecular Hydrogels Towards Enhanced Conductivity

Razaq,

Mehwish,

Xia

et al. 2023

Chemistry A European J

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To comprehend the significance of improved conductive properties in C2‐symmetric hydrogels, it is vital to investigate how non‐gelating achiral functional group isomers influence the conductivity of such supramolecular hydrogels, whereas understanding the major driving forces behind this regulatory process is first and foremost. Herein, we report a hydrogel system containing tryptophan‐conjugated NDI as the backbone (L/D‐NTrp), enabling effective supramolecular assembly with the bipyridyl functional group isomers. This co‐assembly behavior results in materials with exceptional mechanical properties and high conductivities, surpassing most previously reported C2‐symmetrical hydrogels, as well as the ability to form controlled morphologies. Notably, the co‐hydrogels displayed an eight‐fold increase in mechanical strength, making them more robust and resistant to deformation compared to the original gel. Additionally, all hydrogels exhibited favorable electrical conductivity, with the co‐assembled hydrogels showcasing notable performance, making them a promising candidate for use in electronic devices and sensors. This report lays the foundation for further investigation into the properties and potential applications of L/D‐NTrp compound in the range of fields, including drug delivery, tissue engineering, and electronics.

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“…Recently, the principle of chirality transfer in hybrid hydrogels has been developed for molecular recognition of structural isomers [20]. Inspired by this finding, a sucrose triggered chiral supramolecular assembly containing l-phenylalanine based gelator (LPF) [21], and diaminopyridine (DAP) is rationally designed to address the challenge of visual recognition.…”

Section: Introductionmentioning

confidence: 99%

Chirality Transfer in Supramolecular Co-assembled Fibrous Material Enabling the Visual Recognition of Sucrose

et al. 2020

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Molecular recognition of simple sugars is crucial due to their essential roles in most living organisms. However, it remains extremely challenging to achieve a visual recognition of simple sugars like sucrose in water media under physiological conditions. In this article, the visual recognition of sucrose is accomplished by a chiral supramolecular hydrogel formation through the co-assembly of a two-component fibrous solution (l-phenylalanine based gelator co-diaminopyridine, LDAP) and sucrose. H-bonding between the amino group of LDAP and the hydroxyl group of sucrose facilitates the gelation by loading sucrose into the LDAP solution. The formed hydrogel showed an amplified inversion of circular dichroism (CD) signals as compared to the corresponding LDAP solution. In addition, the effective chirality transfer was accompanied by a bathochromic shift in UV-Vis and FL spectra of the gel. Such a simple and straightforward chiral co-assembled strategy to visually recognize sucrose will have the potential use of smart gelators in saccharides separation and proteomics to be further applied in medical diagnostics and cell imaging.

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Molecular recognition of melamine and cyanuric acid by C2-symmetric phenylalanine based supramolecular hydrogels

Cited by 9 publications

References 37 publications

Mussel-Inspired Surface Functionalization of Porous Albumin Cryogels Supporting Synergistic Antibacterial/Antioxidant Activity and Bone-Like Apatite Formation

Mussel-Inspired Surface Functionalization of Porous Albumin Cryogels Supporting Synergistic Antibacterial/Antioxidant Activity and Bone-Like Apatite Formation

NDI based C2‐symmetric Chiral Supramolecular Hydrogels Towards Enhanced Conductivity

Chirality Transfer in Supramolecular Co-assembled Fibrous Material Enabling the Visual Recognition of Sucrose

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