Molecular Phylogeny and Evolutionary Timescale for the Family of Mammalian Herpesviruses

McGeoch, Duncan J.; Cook, Simon; Dolan, Aidan; Jamieson, Fiona E.; Telford, Elizabeth A.R.

doi:10.1006/jmbi.1995.0152

Cited by 434 publications

(329 citation statements)

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“…It is estimated that the three mammalian subfamilies of herpesviruses arose approximately 180-220 million years ago, and recent speciation within subfamilies occurred in the last 80 million years, likely driven, at least in part, by co-evolution with the host (McGeoch et al 1995). Taking into account that at least 90% of the human population is infected with at least one herpesvirus, and herpesvirus infection is largely asymptomatic in immunocompetent individuals, it is likely that herpesviruses provide some benefit to the host (Virgin et al 2009).…”

Section: Associations Between Immune Profile Status Fitness and CMmentioning

confidence: 99%

A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness

Souquette¹,

Frere²,

Smithey³

et al. 2017

GeroScience

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Approximately 50% of individuals aged 6-49 years in the United States are infected with cytomegalovirus (CMV), with seroprevalence increasing with age, reaching 85-90% by 75-80 years according to Bate et al. (Clin Infect Dis 50 (11): 1439-1447 and Pawelec et al. (Curr Opin Immunol 24:507-511, 2012). Following primary infection, CMV establishes lifelong latency with periodic reactivation. Immunocompetent hosts experience largely asymptomatic infection, but CMV can cause serious illness in immunocompromised populations, such as transplant patients and the elderly. Control of CMV requires constant immune surveillance, and recent discoveries suggest this demand alters general features of the immune system in infected individuals. Here, we review recent advances in the understanding of the immune response to CMV and the role of CMV in immune aging and fitness, while highlighting the importance of potential confounding factors that influence CMV studies. Understanding how CMV contributes to shaping Bbaseline^immunity has important implications for a host's ability to mount effective responses to diverse infections and vaccination.

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Section: Associations Between Immune Profile Status Fitness and CMmentioning

confidence: 99%

A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness

Souquette¹,

Frere²,

Smithey³

et al. 2017

GeroScience

View full text Add to dashboard Cite

show abstract

“…Phylogenetic analysis of UDG and other protein sequences from mammalian members of the family Herpes iridae distinguished the three recognized subfamilies, and it was estimated that the three subfamilies arose approx. 180-200 million years ago [53]. UDGs from pox viruses [54][55][56][57][58] are more distantly related, but the active-site region is also highly conserved in these viruses.…”

Section: Udgs Belong To a Highly Conserved Ancient Familymentioning

confidence: 99%

DNA glycosylases in the base excision repair of DNA

Krokan

Standal

Slupphaug

1997

Biochemical Journal

766

566

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A wide range of cytotoxic and mutagenic DNA bases are removed by different DNA glycosylases, which initiate the base excision repair pathway. DNA glycosylases cleave the Nglycosylic bond between the target base and deoxyribose, thus releasing a free base and leaving an apurinic\apyrimidinic (AP) site. In addition, several DNA glycosylases are bifunctional, since they also display a lyase activity that cleaves the phosphodiester backbone 3h to the AP site generated by the glycosylase activity. Structural data and sequence comparisons have identified common features among many of the DNA glycosylases. Their active sites have a structure that can only bind extrahelical target bases, as observed in the crystal structure of human uracil-DNA glycosylase in a complex with double-stranded DNA. Nucleotide flipping is apparently actively facilitated by the enzyme. With bacteriophage T4 endonuclease V, a pyrimidine-

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“…2a). This approach of calibrating one lineage using another, associated, lineage has been applied to endosymbiotic bacteria of aphids (Moran et al, 1993) and cockroaches (Bandi et al, 1995) and alpha herpes viruses of vertebrates (McGeoch et al, 1995). Even if neither member of a cospeciating association has an adequate fossil record we can still obtain a measure of the relative rate of evolution in the two lineages because cospeciation implies that there are events of the same age in the two clades, even if we do not know…”

Section: Introductionmentioning

confidence: 99%

A Different Tempo of Mitochondrial DNA Evolution in Birds and Their Parasitic Lice

Page

Lee

Becher

et al. 1998

Molecular Phylogenetics and Evolution

136

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Molecular Phylogeny and Evolutionary Timescale for the Family of Mammalian Herpesviruses

Cited by 434 publications

References 0 publications

A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness

A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness

DNA glycosylases in the base excision repair of DNA

A Different Tempo of Mitochondrial DNA Evolution in Birds and Their Parasitic Lice

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