Molecular pharmacology of estrogens

Segal, Sheldon J.; Koide, S. S.

doi:10.1016/0163-7258(79)90019-6

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1981

1993

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Cited by 9 publications

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“…The therapeutic effectiveness of estrogen is likely mediated through its interaction with the specific receptors which have been char acterized in a number of target tissues [5,16]. The role of estrogen in the control of its own receptor has not been fully elucidated.…”

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confidence: 99%

Effect of Estradiol and Estriol Treatment on Vaginal Estrogen Receptors in the Ovariectomized Rabbit

Batra

Iosif

Sjögren

1984

Gynecol Obstet Invest

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Wet weight of the vagina increased by more than two-fold following treatment of the ovariectomized rabbits daily for 7 days with 100 µg/kg estradiol- 17Β or estriol. The concentration of estrogen receptors expressed on the basis of milligrams of protein in both the cytosolic and nuclear fractions decreased significantly after treatment with estradiol or estriol. The data reinforce the view that estriol given in low doses over a long period of time has as good an effect as estradiol on the vagina, and its use might be safer with respect to the effect on endometrial proliferation.

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confidence: 99%