2006
DOI: 10.1016/j.gene.2005.10.028
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Abstract: Bone tissue has the capacity to adapt to its functional environment such that its morphology is "optimized" for the mechanical demand. The adaptive nature of the skeleton poses an interesting set of biological questions (e.g., how does bone sense mechanical signals, what cells are the sensing system, what are the mechanical signals that drive the system, what receptors are responsible for transducing the mechanical signal, what are the molecular responses to the mechanical stimuli). Studies of the characterist… Show more

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Cited by 393 publications
(303 citation statements)
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“…From a metabolic perspective, the trend toward improved glucose tolerance measured here indicates that the metabolic machinery of the organism has been elevated, and perhaps remains higher even after LMMS has subsided, suggesting that a mechanosensory element within the cell population has been triggered without the signals being large (24). And rather than requiring an accumulation of mechanical information over an aggregate of time to elevate metabolic activity, perhaps these cell populations are endowed with a memory, or refractory period, in which their metabolic machinery, once triggered, remains active even after the stimulus has subsided (25).…”
Section: Discussionmentioning
confidence: 80%
“…From a metabolic perspective, the trend toward improved glucose tolerance measured here indicates that the metabolic machinery of the organism has been elevated, and perhaps remains higher even after LMMS has subsided, suggesting that a mechanosensory element within the cell population has been triggered without the signals being large (24). And rather than requiring an accumulation of mechanical information over an aggregate of time to elevate metabolic activity, perhaps these cell populations are endowed with a memory, or refractory period, in which their metabolic machinery, once triggered, remains active even after the stimulus has subsided (25).…”
Section: Discussionmentioning
confidence: 80%
“…In our laboratory, such a device has been designed and validated. 8 It has been shown that osteoblasts respond to mechanical signals which play a key role in the formation of bone [9][10][11] ; mechanical stimulation leads to an increase in proliferation and matrix synthesis. 12,13 In particular, in vitro experiments have shown fluid flow to have a number of effects on bone cells.…”
Section: Introductionmentioning
confidence: 99%
“…Mechanical loads can provoke remodeling of bone structure and prevention of bone loss [1][2][3]. Joint loading is one loading modality recently employed as a useful method for inducing bone formation in laboratory animals.…”
Section: Introductionmentioning
confidence: 99%