2016
DOI: 10.18632/aging.101102
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Abstract: Acute lymphoblast leukemia (ALL) is characterized by overproduction of immature white blood cells in the bone marrow. ALL is most common in the childhood and has high (>80%) cure rate. In contrast, acute myeloid leukemia (AML) has far greater mortality rate than the ALL and is most commonly affecting older adults. However, AML is a leading cause of childhood cancer mortality. In this study, we compare gene expression and molecular pathway activation patterns in three normal blood, seven pediatric ALL and seven… Show more

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Cited by 16 publications
(11 citation statements)
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References 49 publications
(55 reference statements)
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“…17 The highest rates are found in male children and children aged 1-4 years. 18 ISSN: 2250-1177 [6] CODEN (USA): JDDTAO…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…17 The highest rates are found in male children and children aged 1-4 years. 18 ISSN: 2250-1177 [6] CODEN (USA): JDDTAO…”
Section: Resultsmentioning
confidence: 99%
“…5 AML is relatively rare in childhood, accounting for 15% to 20% of AL, but the most prevalent among adults. 6 Epidemiological studies of acute childhood leukaemia have examined risk ISSN: 2250-1177 [2] CODEN (USA): JDDTAO factors, including genetic, infectious and environmental factors. The majority is idiopathic: no identified cause.…”
Section: Introductionmentioning
confidence: 99%
“…We used customized electrochemical microchip platform manufactured by CustomArray (USA) enabling direct oligonucleotide synthesis on the array [ 29 ]. We produced the arrays with 6020 oligonucleotide probes corresponding to 3706 human genes involved in 378 intracellular signaling pathways, as described previously [ 30 ]. Following library preparations and hybridizations, the microarray hybridization signals were quantile normalized, and the gene expression data were deposited in Gene Expression Omnibus (GEO) database with the accession number GSE96631.…”
Section: Resultsmentioning
confidence: 99%
“…This method was found useful to suppress bias and batch effects associated with the high throughput profiling of gene expression [ 22 ]. This approach was published to assess the activation of signaling [ 23 ] and metabolic [ 24 ] pathways in numerous objects related to human pathology and aging [ 25 ], such as the cancer tissues [ 26 ] and cell lines [ 27 ], asthma [ 28 ], fibrosis [ 29 ] and progeria [ 30 ]. For pathway activation calculations, for each time point, we took the naïve cells gene expression data as the controls to normalize changes associated with the culturing in the presence of target anticancer drugs.…”
Section: Resultsmentioning
confidence: 99%