Molecular nanoinformatics approach assessing the biocompatibility of biogenic silver nanoparticles with channelized intrinsic steatosis and apoptosis

Panda, Pritam Kumar; Kumari, Puja; Patel, Paritosh; Samal, Shailesh Kumar; Mishra, Sarita; Tambuwala, Murtaza M.; Dutt, A.; Hilscherová, Klára; Mishra, Yogendra Kumar; Varma, Rajender S.; Suar, Mrutyunjay; Ahuja, Rajeev; Verma, Suresh K.

doi:10.1039/d1gc04103g

Cited by 22 publications

(7 citation statements)

References 69 publications

(95 reference statements)

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“…However, both computational and experimental analysis was utilized in a concentration-dependent manner, the AgNPs enhanced oxidative stress accumulation and internalization depending on an intrinsic atomic interaction with the proteins, including sod1, tp53, and apoa1-mttp. In addition, it was ascertained that the biogenic AgNPs developed from silver grass were significantly biocompatible and eco-compatible and could be used for biomedical and ecological applications [ 30 ]. Silver nanoparticles, those developed via biogenic essence are proven to be biocompatible, such as oligodynamic characteristics of such biogenic NPs have been explored for thousands of years ago.…”

Section: Introductionmentioning

confidence: 99%

Polyphenol-Capped Biogenic Synthesis of Noble Metallic Silver Nanoparticles for Antifungal Activity against Candida auris

Malik

Batterjee

Kamli

et al. 2022

JoF

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In terms of reduced toxicity, the biologically inspired green synthesis of nanoparticles has emerged as a promising alternative to chemically fabricated nanoparticles. The use of a highly stable, biocompatible, and environmentally friendly aqueous extract of Cynara cardunculus as a reducing and capping agent in this study demonstrated the possibility of green manufacturing of silver nanoparticles (CC-AgNPs). UV–visible spectroscopy validated the development of CC-AgNPs, indicating the surface plasmon resonance (SPR) λmax band at 438 nm. The band gap of CC-AgNPs was found to be 2.26 eV. SEM and TEM analysis examined the surface morphology of CC-AgNPs, and micrographs revealed that the nanoparticles were spherical. The crystallinity, crystallite size, and phase purity of as-prepared nanoparticles were confirmed using XRD analysis, and it was confirmed that the CC-AgNPs were a face-centered cubic (fcc) crystalline-structured material. Furthermore, the role of active functional groups involved in the reduction and surface capping of CC-AgNPs was revealed using the Fourier transform infrared (FTIR) spectroscopic technique. CC-AgNPs were mostly spherical and monodispersed, with an average size of 26.89 nm, and were shown to be stable for a longer period without any noticeable change at room temperature. Further, we checked the antifungal mechanism of CC-AgNPs against C. auris MRL6057. The minimum inhibitory concentrations (MIC) and minimum fungicidal concentrations (MFC) were 50.0 µg/mL and 100.0 µg/mL respectively. The cell count and viability assay confirmed the fungicidal potential of CC-AgNPs. Further, the analysis showed that CC-AgNPs could induce apoptosis and G2/M phase cell cycle arrest in C. auris MRL6057. Our results also suggest that the CC-AgNPs were responsible for the induction of mitochondrial toxicity. TUNEL assay results revealed that higher concentrations of CC-AgNPs could cause DNA fragmentation. Therefore, the present study suggested that CC-AgNPs hold the capacity for antifungal drug development against C. auris infections.

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Section: Introductionmentioning

confidence: 99%

Polyphenol-Capped Biogenic Synthesis of Noble Metallic Silver Nanoparticles for Antifungal Activity against Candida auris

Malik

Batterjee

Kamli

et al. 2022

JoF

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“…An in vitro study showed that AgNPs are cytotoxic to different types of cells, including cells from the human endocrine system, germ cells, and skin, liver, kidney, lung, and brain [ 196 ] cells. In a recent investigation by Panda and Kumari et al, a novel combinatorial technique was used to investigate the function of various AgNP–protein interactions via the first-principle density functional theory and an in silico analysis [ 197 ]. From such investigations, it is possible to speculate that nanoparticles created using plant proteins in a newer method will be more biocompatible and environmentally friendly.…”

Section: Toxicity-based Investigations Of Agnpsmentioning

confidence: 99%

Emerging Trends in Advanced Translational Applications of Silver Nanoparticles: A Progressing Dawn of Nanotechnology

Husain

Nandi

Simnani

et al. 2023

JFB

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Nanoscience has emerged as a fascinating field of science, with its implementation in multiple applications in the form of nanotechnology. Nanotechnology has recently been more impactful in diverse sectors such as the pharmaceutical industry, agriculture sector, and food market. The peculiar properties which make nanoparticles as an asset are their large surface area and their size, which ranges between 1 and 100 nanometers (nm). Various technologies, such as chemical and biological processes, are being used to synthesize nanoparticles. The green chemistry route has become extremely popular due to its use in the synthesis of nanoparticles. Nanomaterials are versatile and impactful in different day to day applications, resulting in their increased utilization and distribution in human cells, tissues, and organs. Owing to the deployment of nanoparticles at a high demand, the need to produce nanoparticles has raised concerns regarding environmentally friendly processes. These processes are meant to produce nanomaterials with improved physiochemical properties that can have significant uses in the fields of medicine, physics, and biochemistry. Among a plethora of nanomaterials, silver nanoparticles have emerged as the most investigated and used nanoparticle. Silver nanoparticles (AgNPs) have become vital entities of study due to their distinctive properties which the scientific society aims to investigate the uses of. The current review addresses the modern expansion of AgNP synthesis, characterization, and mechanism, as well as global applications of AgNPs and their limitations.

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“…Several nanoparticles synthesized to kill cancer cells using the Fenton chemical method are Fe 2 O 3 , MnFe 2 O 4 [196], FeO x -MSNs [197], silver [198], gold [199] and α-Fe 2 O 3 [192,200]. low efficiency of the Fenton mechanism to release OH-led to the addition of a few other therapeutic approaches like chemotherapy, photothermal therapy (PTT), and photo-fenton to the reaction [201] (Fig. 6).…”

Section: Nanobiomaterials Driven Direct Cancer Therapy Approachmentioning

confidence: 99%

The translational paradigm of nanobiomaterials: Biological chemistry to modern applications

Sinha

Simnani

Singh

et al. 2022

Materials Today Bio

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Molecular nanoinformatics approach assessing the biocompatibility of biogenic silver nanoparticles with channelized intrinsic steatosis and apoptosis

Abstract: The developmental rapidity of nanotechnology poses the higher risks of exposure to humans and the environment through manufactured nanomaterials. The multitude of biological interfaces, like DNA, proteins, membranes, and cell...

Cited by 22 publications

References 69 publications

Polyphenol-Capped Biogenic Synthesis of Noble Metallic Silver Nanoparticles for Antifungal Activity against Candida auris

Polyphenol-Capped Biogenic Synthesis of Noble Metallic Silver Nanoparticles for Antifungal Activity against Candida auris

Emerging Trends in Advanced Translational Applications of Silver Nanoparticles: A Progressing Dawn of Nanotechnology

The translational paradigm of nanobiomaterials: Biological chemistry to modern applications

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