Molecular modelling as a tool for studying the disassembly of potentially leishmanicide-targeted dendrimer

Santos, Soraya da Silva; Giarolla, Jeanine; Pasqualoto, Kerly Fernanda Mesquita; Ferreira, Elizabeth Igne

doi:10.1080/08927022.2013.774086

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General Applications Of Dendrimer Prodrugs1

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2015

2024

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Cited by 5 publications

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“…Dendrimeric prodrugs with four, five and six branches revealed that carbonyl group near the core were the most promising ester breaking point [58,59]. The same approach was analyzed by Santos and colleagues [60,61]. Therein, the authors evaluated the disassembly of targeted dendrimer useful against leishmaniasis.…”

Section: General Applications Of Dendrimer Prodrugsmentioning

confidence: 99%

Dendrimer Prodrugs

2016

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Abstract:The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field. Therefore, the use of dendrimer prodrugs as carrier for drug delivery, to improve pharmacokinetic properties of prototype, to promote drug sustained-release, to increase selectivity and, consequently, to decrease toxicity, are just some examples of topics that have been extensively reported in the literature, especially in the last decade. The examples discussed here give a panel of the growing interest dendrimer prodrugs have been evoking in the scientific community.

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Section: General Applications Of Dendrimer Prodrugsmentioning

confidence: 99%