Molecular mimicry of Aggregatibacter actinomycetemcomitans with β2 glycoprotein I

Abstract

The results suggest that A. actinomycetemcomitans infection may elicit anti-SIRVYK IgG antibodies and modify the anti-TLRVYK antibody response in patients with periodontitis by molecular mimicry with beta2GPI.

Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases

“…It has been hypothesized that some anti-CL found in patients without autoimmune disease may result from molecular mimicry of microbial origin (Blank et al 2002). In fact, Wang (Wang et al 2008) demonstrated that patients with A. actinomycetemcomitans infection displayed elevated antibody concentrations to the peptide SIRVYK, a sequence found in A. actinomycetemcomitans that is homologous to TLRVYK. Furthermore, anti-SIRVYK correlated with anti-TLRVYK in patients colonized with A. actinomycetemcomitans.…”

Autoantibodies specific to a peptide of β2-glycoprotein I cross-react with TLR4, inducing a proinflammatory phenotype in endothelial cells and monocytes

“…Because previous studies demonstrated that ␤ 2 GPI shares epitope homology with certain microbial pathogens 37 such as periodontal pathogens, 38 we compared the peptide sequence with known microbial sequences in the Swiss-Prot database using BLASTP. We found that the peptide sequence shared a complete identity (100%) with an epitope of P gingivalis RNA polymerase -70 factor (PDDLPFST; Figure 2A).…”

Host–microbial co-evolution in periodontitis associated with Aggregatibacter actinomycetemcomitans infection

“…If bacteria have molecular mimicry with a host peptide, immune responses to the bacteria might also attack the host molecule that shares the same sequence, and this autoimmune function might induce systemic diseases [23,24]. Molecular mimicry between periodontopathic bacteria and host molecules, e.g., heat shock proteins [25], β2-glycoprotein I [26], and citrullinated enolase [27], has been reported by several investigators. Antibody response to periodontopathic bacteria is important to protect the periodontal tissue from bacteria.…”