Molecular mechanisms of the antiglycative and cardioprotective activities of<i>Psidium guajava</i>leaves in the rat diabetic myocardium

Soman, Sowmya; Rajamanickam, C.; Rauf, Arun A.; Indira, M.

doi:10.1080/13880209.2016.1207090

Cited by 9 publications

(8 citation statements)

References 31 publications

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“…After the induction of diabetes by STZ (55 mg/kg) in female Sprague Dawley rats, QCT or Psidium guajava extract, respectively, was administered for 60 days. Both treatments were accompanied with decreased levels of AGEs (advanced glycation end products) in the diabetic heart suggesting beneficial cardiac effects of QCT in diabetic subjects [106]. Moreover, cardioprotective effects of QCT and rutin (QCT derivative) were documented in I/R-induced myocardial infarction in both normal and diabetic rats.…”

Section: Role Of Comorbidities In Cardioprotection By Qct and Its Dermentioning

confidence: 95%

“…In addition, ameliorated histopathological changes, oxidative stress, inflammation and apoptosis levels were observed [103]. In the study of Soman et al [106], it was found that pure QCT (50 mg/kg) as well as extract from Psidium guajava (a plant highly enriched with QCT) showed beneficial effects on the diabetic heart. After the induction of diabetes by STZ (55 mg/kg) in female Sprague Dawley rats, QCT or Psidium guajava extract, respectively, was administered for 60 days.…”

Section: Role Of Comorbidities In Cardioprotection By Qct and Its Dermentioning

confidence: 96%

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Potential Implications of Quercetin and its Derivatives in Cardioprotection

Ferenczyová

Kaločayová

Barteková

2020

IJMS

102

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Quercetin (QCT) is a natural polyphenolic compound enriched in human food, mainly in vegetables, fruits and berries. QCT and its main derivatives, such as rhamnetin, rutin, hyperoside, etc., have been documented to possess many beneficial effects in the human body including their positive effects in the cardiovascular system. However, clinical implications of QCT and its derivatives are still rare. In the current paper we provide a complex picture of the most recent knowledge on the effects of QCT and its derivatives in different types of cardiac injury, mainly in ischemia-reperfusion (I/R) injury of the heart, but also in other pathologies such as anthracycline-induced cardiotoxicity or oxidative stress-induced cardiac injury, documented in in vitro and ex vivo, as well as in in vivo experimental models of cardiac injury. Moreover, we focus on cardiac effects of QCT in presence of metabolic comorbidities in addition to cardiovascular disease (CVD). Finally, we provide a short summary of clinical studies focused on cardiac effects of QCT. In general, it seems that QCT and its metabolites exert strong cardioprotective effects in a wide range of experimental models of cardiac injury, likely via their antioxidant, anti-inflammatory and molecular pathways-modulating properties; however, ageing and presence of lifestyle-related comorbidities may confound their beneficial effects in heart disease. On the other hand, due to very limited number of clinical trials focused on cardiac effects of QCT and its derivatives, clinical data are inconclusive. Thus, additional well-designed human studies including a high enough number of patients testing different concentrations of QCT are needed to reveal real therapeutic potential of QCT in CVD. Finally, several negative or controversial effects of QCT in the heart have been reported, and this should be also taken into consideration in QCT-based approaches aimed to treat CVD in humans.

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Section: Role Of Comorbidities In Cardioprotection By Qct and Its Dermentioning

confidence: 95%

Section: Role Of Comorbidities In Cardioprotection By Qct and Its Dermentioning

confidence: 96%

Potential Implications of Quercetin and its Derivatives in Cardioprotection

Ferenczyová

Kaločayová

Barteková

2020

IJMS

102

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“…Translocation of NFκB, and expression of TGF-β1, CTGF, and BNP In vivo [43] Cardioprotective effects restoring plasma thyroid hormone levels and attenuating oxidative stress in the heart…”

Section: Role Mode Referencementioning

confidence: 99%

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Bhat

2021

Biology

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Quercetin, a bioactive secondary metabolite, holds incredible importance in terms of bioactivities, which has been proved by in vivo and in vitro studies. The treatment of cardiovascular and neurological diseases by quercetin has been extensively investigated over the past decade. Quercetin is present naturally in appreciable amounts in fresh produce (fruits and vegetables). However, today, corresponding to the growing population and global demand for fresh fruits and vegetables, a paradigm shift and focus is laid towards exploring industrial food wastes and/or byproducts as a new resource to obtain bioactive compounds such as quercetin. Based on the available research reports over the last decade, quercetin has been suggested as a reliable therapeutic candidate for either treating or alleviating health issues, mainly those of cardiovascular and neurological diseases. In the present review, we have summarized some of the critical findings and hypotheses of quercetin from the available databases foreseeing its future use as a potential therapeutic agent to treat cardiovascular and neurological diseases. It is anticipated that this review will be a potential reference material for future research activities to be undertaken on quercetin obtained from fresh produce as well as their respective processing wastes/byproducts that rely on the circular concept.

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“…The synthesis of BNP induced by mechanical stress on cardiomyocytes is most likely achieved by the mechanical stress-induced synthesis of ET-1 [14,15,16,17]. ET-1 can also lead to myocardial fibrosis by stimulating transforming growth factor-beta 1 (TGF-β1), which plays a vital role in the occurrence and development of cardiac diseases such as cardiomyopathy, heart valve disease, and arrhythmias [18,19,20]. In the hearts of newborn mice, hypoxia can induce TGF-β1 to activate various signaling pathways that act on the promoter of BNP, eventually activating the expression of BNP [21].…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, BNP can inhibit cardiac fibroblasts by blocking TGF-β1/Smad signaling [22]. Coinstantaneous upregulated TGF-β1 and BNP during myocardial remodeling in rats also indicates a possible relationship between these factors [20,22].…”

Section: Introductionmentioning

confidence: 99%

The Expression of BNP, ET-1, and TGF-β1 in Myocardium of Rats with Ventricular Arrhythmias

Tian¹,

Xiao²,

Xue³

et al. 2019

IJMS

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Ventricular arrhythmia (VA) is a major component of sudden cardiac death (SCD). To investigate the expression of brain natriuretic peptide (BNP), endothelin-1 (ET-1), and transforming growth factor-beta 1 (TGF-β1) during VA, we established a rat model of VA induced by BaCl2 solution through a microinjector pump. PD142893 (ET-1 receptor blocker) and SB431542 (TGF-β1 receptor type I blocker) were used to explore the effect of ET-1 and TGF-β1 on BNP expression in the myocardium after VA. BNP, ET-1, and TGF-β1 in rat myocardium were assayed by western blot and immunohistochemical staining for proteins, and real-time quantitative polymerase chain reaction for mRNAs. We found increased expression of BNP and ET-1 in rat myocardium that was associated with the duration of VA. However, TGF-β1 protein expression remained unchanged. Such early increases in BNP and ET-1 may be attributed to fatal arrhythmias associated with SCD, suggesting these may be novel biomarkers of this disease. After intraperitoneal injection of PD142893 and SB431542, respectively, BNP was downregulated in the myocardium of the left ventricle; however, this was abrogated by co-application of the two inhibitors. These results suggested that both ET-1 and TGF-β1, by specifically binding to their receptors, might be involved in the myocardial synthesis of BNP during VA in vivo.

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Molecular mechanisms of the antiglycative and cardioprotective activities ofPsidium guajavaleaves in the rat diabetic myocardium

Cited by 9 publications

References 31 publications

Potential Implications of Quercetin and its Derivatives in Cardioprotection

Potential Implications of Quercetin and its Derivatives in Cardioprotection

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

The Expression of BNP, ET-1, and TGF-β1 in Myocardium of Rats with Ventricular Arrhythmias

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