2011
DOI: 10.1038/onc.2011.384
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Abstract: Platinum-based drugs, and in particular cis-diamminedichloroplatinum(II) (best known as cisplatin), are employed for the treatment of a wide array of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions followed by the activation of the DNA damage response and the induction of mitochondrial apoptosis. D… Show more

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Cited by 2,075 publications
(1,900 citation statements)
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References 171 publications
(180 reference statements)
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“…Cisplatin binds to the DNA strand and hinders both DNA replication and RNA translation and eventually trigger mitochondrial apoptosis (Kelland 2007). Despite a consistent rate of initial responses, cisplatin treatment often results in therapeutic failure because of development of chemo resistance (Galluzzi et al 2012). Therefore, vast researches are in progress for introduce new therapeutic agents to restore the sensitivity of resistant cancer cells.…”
Section: Resultsmentioning
confidence: 99%
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“…Cisplatin binds to the DNA strand and hinders both DNA replication and RNA translation and eventually trigger mitochondrial apoptosis (Kelland 2007). Despite a consistent rate of initial responses, cisplatin treatment often results in therapeutic failure because of development of chemo resistance (Galluzzi et al 2012). Therefore, vast researches are in progress for introduce new therapeutic agents to restore the sensitivity of resistant cancer cells.…”
Section: Resultsmentioning
confidence: 99%
“…Non-ionizing electromagnetic fields, from extremely-low frequency to radiofrequency, have been shown to cause biological effects even at low intensity. Some of these effects may be applied to medical treatments (Galluzzi et al 2012). A recent example is that, several reports have evaluated the effects of EL-EMF on tissue repair (Lai and Singh 2010).…”
Section: Introductionmentioning
confidence: 99%
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“…Platinum resistance is well defined and relies on altered drug metabolism, repair of sub-lethal DNA damage, and inhibition of apoptosis [4,5]. The concept of platinum-sensitive recurrence catalyzed interest in alternate cellular interactions explaining sensitivity with platinum re-challenge, with the tumor microenvironment emerging as an active area of investigation.…”
Section: Tumor Microenvironmentmentioning
confidence: 99%
“…These side effects are so severe that they limit the dose that patients are able to tolerate, and as such, a sub-lethal dose may be delivered to the tumour. Subsequently, a sub-lethal dose of drug administered to the tumour gives rise to drug resistance [2], which is a particular problem in the treatment of ovarian cancer [3]. Therefore, instead of the continued development of new platinum drugs, which might result in drugs that are more cytotoxic but display the same or more severe level of toxicity (i.e.…”
Section: Introductionmentioning
confidence: 99%