Molecular mechanism of the endothelin receptor type B interactions with Gs, Gi, and Gq
Donghee Ham,
Wataru Shihoya,
Osamu Nureki
et al.
Abstract:The endothelin receptor type B (ETB) exhibits promiscuous coupling with various G protein subtypes including Gs, Gi/o, Gq/11, and G12/13, leading to multi-modal signal transduction. Recent fluorescence and structural studies have raised questions regarding the coupling efficiencies and determinants of these G protein subtypes. Herein, by utilizing an integrative approach, combining hydrogen/deuterium exchange mass spectrometry and NanoLuc Binary Technology-based cellular systems, we investigated conformational… Show more
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