Molecular mechanism of tanshinone IIA and cryptotanshinone in platelet anti-aggregating effects: an integrated study of pharmacology and computational analysis

Μaione, Francesco; Cantone, Vincenza; Chini, Maria Giovanna; Feo, Vincenzo De; Mascolo, Nicola; Bifulco, Giuseppe

doi:10.1016/j.fitote.2014.11.024

Cited by 70 publications

(33 citation statements)

References 15 publications

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“…The case of Radix Salvia miltiorrhiza was used for demonstrating the potential application of this method. Substantial evidence has shown that Tanshinone IIA is one of the main pharmacologically active ingredients in Radix Salvia miltiorrhiza . Our radar chart analysis suggests that Tanshinone IIA is a typical strong retention compound in the C 18 column (Supporting Information Fig.…”

Section: Discussionmentioning

confidence: 69%

Five‐descriptor model to predict the chromatographic sequence of natural compounds

Hou

Wang

et al. 2016

J of Separation Science

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Despite the recent introduction of mass detection techniques, ultraviolet detection is still widely applied in the field of the chromatographic analysis of natural medicines. Here, a neural network cascade model consisting of nine small artificial neural network units was innovatively developed to predict the chromatographic sequence of natural compounds by integrating five molecular descriptors as the input. A total of 117 compounds of known structure were collected for model building. The order of appearance of each compound was determined in gradient chromatography. Strong linear correlation was found between the predicted and actual chromatographic position orders (Spearman's rho = 0.883, p < 0.0001). Application of the model to the external validation set of nine natural compounds was shown to dramatically increase the prediction accuracy of the real chromatographic order of multiple compounds. A case study shows that chromatographic sequence prediction based on a neural network cascade facilitated compound identification in the chromatographic fingerprint of Radix Salvia miltiorrhiza. For natural medicines of known compound composition, our method provides a feasible means for identifying the constituents of interest when only ultraviolet detection is available.

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Section: Discussionmentioning

confidence: 69%

Five‐descriptor model to predict the chromatographic sequence of natural compounds

Hou

Wang

et al. 2016

J of Separation Science

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“…These evidences were also supported by a related original research published in 2015. 16 In this study, CRY in vitro was able to inhibit in a concentration dependent manner (0.5-50 µM) the rat platelet aggregation and in silico was able to establish interactions with P2Y12R receptor. This computational method was also performed for TIIA demonstrating even for this diterpenoid an interaction with the same receptor.…”

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confidence: 66%

Danshen and the Cardiovascular System: New Advances for an Old Remedy

Maione

Mascolo

2016

Semin Thromb Hemost

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A recent article published in this journal, entitled "The influence of herbal medicine on platelet function and coagulation: a narrative review," by McEwen, 1 nicely reviewed how herbal medicines can play a role in modifying cardiovascular diseases (CVDs), and also highlighted the interaction of herbal medicines with standard anticoagulant medicinal therapy. Here, we wish to further reflect on the effects of Danshen on the cardiovascular system, and also to report the novel underlying mechanism of its main constituents on platelets function and hemostasis. To our knowledge, these aspects have not been previously fully described.CVDs are the main causes of morbidity and mortality worldwide. 2 They include myocardial infarction, stroke, rheumatic heart disease, and also peripheral artery disease and venous thrombosis. 3 The underlying mechanisms diverge depending on the disease in question. 4 Scientists working on CVDs agree that in most cases hyper-platelet aggregation seems to be a crucial step in cardiovascular hemostasis and in the development and progression of CVDs. For these reasons, pharmacological therapies with agents that modulate platelet reactivity have proven to be effective in the treatment and/or in the prevention of CVDs. 5 Moreover, advancements in technology and better knowledge of both platelet biology and biological functions of natural products have facilitated this process and pushed researchers to search for new and more reliable targets. Finally, but not less important, research into natural compounds founded on their ethnopharmacological information, has provided significant contributions to drug improvement and has paved the way for new pharmacological tools. 6 Danshen has been widely used in traditional folk medicine in China and, to a lesser extent, within the United States and several European countries to treat CVDs and cerebrovascular diseases. 7 Its cardiovascular beneficial actions are attributable to "thinning" the blood and reducing blood clotting, as well as to "invigorate" the blood or improve circulation. Although Danshen is officially listed in the Chinese Pharmacopeia, the cardiovascular pharmacology of its active constituents has not yet been fully described. To date, more than 40 lipophilic tanshinones and 50 hydrophilic phenolics-like compounds have been isolated from Danshen root and extensively investigated for their cardiovascular activities. 8 If we had to promote an "ideal candidate" from one of these lipophilic/phenolics-like compounds in the context of CVDs, this would be without any doubt tanshinone IIA (TIIA) and cryptotanshinone (CRY). Indeed, the discovery of these derivatives of phenanthrene-quinone isolated from Danshen have completely changed the way we look at many Danshen-mediated pharmacological properties. 9 Recently, the pharmacological properties of TIIA and CRY in the cardiovascular system have attracted great interest. Emerging experimental studies and clinical trials have demonstrated that both the compounds prevent atherosclerosis and atherogenesi...

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“…Despite the rapid progresses in the development of several treatments of inflammatory pain, the efficacy and tolerability of conventional analgesics can be overshadowed by their unwanted side effects. The research on natural products, founded on their ethnopharmacological information, has provided significant contributions to drug improvement by the discovery of novel chemical structures and/or mechanism of actions in this respect (Rates, ; Maione et al , ; Maione et al , ; Maione et al , ; Zhao et al , ; Maione et al , ).…”

Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions

Μaione

Cantone

Pace

et al. 2016

British J Pharmacology

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Molecular mechanism of tanshinone IIA and cryptotanshinone in platelet anti-aggregating effects: an integrated study of pharmacology and computational analysis

Cited by 70 publications

References 15 publications

Five‐descriptor model to predict the chromatographic sequence of natural compounds

Five‐descriptor model to predict the chromatographic sequence of natural compounds

Danshen and the Cardiovascular System: New Advances for an Old Remedy

Anti‐inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions

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