Molecular mechanism of liver X receptors in cancer therapeutics

Wang, Qiang; Wang, Jing; Wang, Jiayou; Zhang, Heng

doi:10.1016/j.lfs.2021.119287

Cited by 7 publications

(4 citation statements)

References 89 publications

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“…Some studies have indicated that the abnormal expression of LXRs is a potential tumor-specific signature and can be involved in the clinical characteristics of malignant tissues, suggesting the indelible role of LXRs in different types of tumors [ 12 ]. LXRα might be related to tumor cell proliferation, differentiation, progression, and metastasis, and could be regarded as a potential prognostic and diagnostic biomarker in carcinogenesis.…”

Section: Biological Functions and Mechanisms Of Lxrα In Diverse Cancersmentioning

confidence: 99%

“…However, their role in tumorigenesis and tumor development is still unclear. Previous studies have shown that the patterns of LXRα expression between cancer and normal tissues are diverse and depend on cancer types [12]. Therefore, we used the Oncomine database (https://www.oncomine.org/, accessed on 22nd August 2021) to analyze LXRα expression over a wide range of cancers [30].…”

Section: The Expression Of Lxrα In Different Tumor Tissuesmentioning

confidence: 99%

“…In recent years, an increasing number of studies in vitro and in vivo have shown that LXRα may be an important factor in the proliferation, apoptosis, invasion, and migration of cancer cells [ 12 ]. The abnormal expression of LXRα can be observed in many cancers and has a strong relationship with the clinical outcome.…”

Section: Introductionmentioning

confidence: 99%

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Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers

Han,

Yuan,

Yan

et al. 2023

Biomolecules

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Liver X receptor α (LXRα), a member of the nuclear receptor superfamily, is identified as a protein activated by ligands that interacts with the promoters of specific genes. It regulates cholesterol, bile acid, and lipid metabolism in normal physiological processes, and it participates in the development of some related diseases. However, many studies have demonstrated that LXRα is also involved in regulating numerous human malignancies. Aberrant LXRα expression is emerging as a fundamental and pivotal factor in cancer cell proliferation, invasion, apoptosis, and metastasis. Herein, we outline the expression levels of LXRα between tumor tissues and normal tissues via the Oncomine and Tumor Immune Estimation Resource (TIMER) 2.0 databases; summarize emerging insights into the roles of LXRα in the development, progression, and treatment of different human cancers and their diversified mechanisms; and highlight that LXRα can be a biomarker and therapeutic target in diverse cancers.

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Section: Biological Functions and Mechanisms Of Lxrα In Diverse Cancersmentioning

confidence: 99%

Section: The Expression Of Lxrα In Different Tumor Tissuesmentioning

confidence: 99%

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Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers

Han,

Yuan,

Yan

et al. 2023

Biomolecules

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“…Besides, LXRs have important effects on the metabolism of phospholipids [ 238 ]. LXRs play a divergent role in tumorigenesis, functioning as either tumor‐suppressors or tumor‐promoter dependent on the cell types and animal species [ 239 , 240 ]. Thus, the roles of LXRs deserve further elaboration in PC.…”

Section: Alterations Of Lipid Metabolism In Pcmentioning

confidence: 99%

Lipid metabolism in pancreatic cancer: emerging roles and potential targets

Yin

Song

et al. 2022

Cancer Communications

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Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5-year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection. Surgical resection represents the only chance for cure, but treatment options are limited for advanced diseases, such as distant metastatic or locally progressive tumors. Although adjuvant chemotherapy has improved long-term outcomes in advanced cancer patients, its response rate is low. So, exploring other new treatments is urgent. In recent years, increasing

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Implication of Oxysterols and Phytosterols in Aging and Human Diseases

Vigne,

Pot

2023

Advances in Experimental Medicine and Biology

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Molecular mechanism of liver X receptors in cancer therapeutics

Cited by 7 publications

References 89 publications

Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers

Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers

Lipid metabolism in pancreatic cancer: emerging roles and potential targets

Implication of Oxysterols and Phytosterols in Aging and Human Diseases

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