Molecular link between dietary fibre, gut microbiota and health

Kumar, Jitendra; Datt, Chander

doi:10.1007/s11033-020-05611-3

Cited by 130 publications

(96 citation statements)

References 68 publications

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“…In the current study, acetate is the most abundant SCFA, followed by propionate and butyrate in both faeces and plasma, which is consistent with previous study [25]. The molar ratio of acetate, propionate and butyrate in faeces is 66:23:11 in sows in this study, a little different with that in human faeces, 60:20:20 [9]. Functionally, acetate can be used to produce propionate and butyrate [5], and involved in liver lipogenesis and lipolysis in adipose tissue [26].…”

Section: Discussionsupporting

confidence: 91%

“…A plethora of studies have associated intake of dietary bre with the change of composition and function of gut microbiome [6][7][8]. The production of symbiotic metabolites by gut microbiome had been proposed to play roles in gut microbiome affecting host physiology [9]. Dietary bres, including nonstarch polysaccharides, oligosaccharides and resistant starches, are microbiota-accessible carbohydrates and fermented by gut microbiome to produce various symbiotic metabolites [9].…”

Section: Introductionmentioning

confidence: 99%

“…The production of symbiotic metabolites by gut microbiome had been proposed to play roles in gut microbiome affecting host physiology [9]. Dietary bres, including nonstarch polysaccharides, oligosaccharides and resistant starches, are microbiota-accessible carbohydrates and fermented by gut microbiome to produce various symbiotic metabolites [9]. Short-chain fatty acids (SCFAs) are one major type of symbiotic metabolites [10], which decrease the pH in the gut lumen to suppress the bacterial growth, and serving as an energy substrate of the host [11].…”

Section: Introductionmentioning

confidence: 99%

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The Improvement of Parturition Progress by High Intake of Dietary Fibre in Late Gestation is Associated with the Altered Gut Microbiome and Metabolome in Sows

Liu¹,

Jiang²,

Chen³

et al. 2020

Preprint

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Background: Gestational intake of dietary fibre improves the parturition progress, which largely affects developmental outcomes of the offspring. Dietary fibre can alter the gut microbiome and production of symbiotic metabolites, e.g. short chain fatty acids (SCFAs). We hypothesized that the improvement of parturition progress by dietary fibre is associated with the symbiotic metabolites generated by the gut microbiome. Methods: Yorkshire sows were randomly given diet containing normal level of fibre (NDF, 16.2% dietary fibre, n = 20) or high level (HDF, 30.1%, n = 20) with other nutrients identical from days 90 of gestation to parturition. Faecal microbiome profiled with 16S amplicon sequencing, SCFAs and metabolome in the faeces and plasma around parturition were compared between the dietary groups. Correlation analysis was conducted to further explore the potential associations between specific bacterial taxa and metabolites. Results: HDF significantly improved the parturition progress, indicated by the shorter parturition duration. HDF increased abundance of the phyla Bacteroidetes and Synergistetes and multiple genera. Except for butyrate, SCFAs levels in the faeces and plasma of sows at parturition were increased in HDF group. The abundances of 15 and 12 metabolites in the faeces and plasma, respectively, markedly differ between HDF and NDF sows. These metabolites are involved in the bacterial metabolism of amino acids, bile acids, SCFAs and dietary fibre. Correlation analysis also showed associations between specific taxa (genera Cellulosilytica and Lachnoclostridia) and metabolites (acetate and isobutyrate).Conclusions: The improvement of parturition process by high fibre intake in late gestation is associated with altered gut microbiome, production of SCFAs and other metabolites, potentially serving for energy metabolism.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Improvement of Parturition Progress by High Intake of Dietary Fibre in Late Gestation is Associated with the Altered Gut Microbiome and Metabolome in Sows

Liu¹,

Jiang²,

Chen³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…These associations may yield potential therapeutic avenues for dietary modifications and prebiotic or probiotic supplementation as complimentary to treatment and to support cancer prevention [107]. Fiber intake plays a notable role in shaping the gut microbiota [115]. The American Institute of Cancer Research endorses a diet high in fruits, vegetables, whole grains, and legumes and low in processed and red meats as cancer preventative [116].…”

Section: Diet Prebiotics and Probiotics In Relationship To Breast Cmentioning

confidence: 99%

“…Butyrate is the primary protective SCFA and its intestinal concentration is dependent on both diet and the intestinal microbiota [126,127]. The chief short chain fatty acids produced by the gut microbiota include butyrate, propionate, and acetate which are metabolic products of microbial fermentation of dietary fiber [115]. Aside from serving as an energy source for colonocytes, butyrate can prevent histone de-acetylases from making epigenetic modifications that can lead to tumorigenesis [126,128].…”

Section: Diet Prebiotics and Probiotics In Relationship To Breast Cmentioning

confidence: 99%

The Gut Microbiota: A Potential Gateway to Improved Health Outcomes in Breast Cancer Treatment and Survivorship

Sampsell

Hao²,

Reimer

2020

IJMS

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Breast cancer is the most frequently diagnosed cancer in women worldwide. The disease and its treatments exert profound effects on an individual’s physical and mental health. There are many factors that impact an individual’s risk of developing breast cancer, their response to treatments, and their risk of recurrence. The community of microorganisms inhabiting the gastrointestinal tract, the gut microbiota, affects human health through metabolic, neural, and endocrine signaling, and immune activity. It is through these mechanisms that the gut microbiota appears to influence breast cancer risk, response to treatment, and recurrence. A disrupted gut microbiota or state of ‘dysbiosis’ can contribute to a biological environment associated with higher risk for cancer development as well as contribute to negative treatment side-effects. Many cancer treatments have been shown to shift the gut microbiota toward dysbiosis; however, the microbiota can also be positively manipulated through diet, prebiotic and probiotic supplementation, and exercise. The objective of this review is to provide an overview of the current understanding of the relationship between the gut microbiota and breast cancer and to highlight potential strategies for modulation of the gut microbiota that could lead to improved clinical outcomes and overall health in this population.

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Xylo‐oligosaccharides improve functional constipation by targeted enrichment of Bifidobacterium

Yi,

Wang,

Xue

et al. 2023

Food Science & Nutrition

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Functional constipation (FC) has a negative impact on patients' quality of life. We hypothesized that dietary supplementation with xylo‐oligosaccharides (XOS) or fructo‐oligosaccharides (FOS) would improve constipation symptoms by influencing the gut microbiota. A randomized double‐blind controlled trial was conducted in FC patients. Patients were randomly divided into 6 groups and given a dietary supplement containing XOS at doses of 3, 5, or 10 g/day, FOS at doses of 10 and 20 g/day, or placebo at 5 g/day for one month. We compared improvements in gastrointestinal function after the intervention using the Bristol Stool Form Scale (BSFS), Cleveland Clinic Constipation Score (CCCS), and Quality of Life Scale for Patients with Constipation (PAC‐QoL). 16S rRNA sequencing was used to assess changes in the structure of the gut microbiota. Changes in individual bacteria had significant effects in reducing gastrointestinal symptoms during the intervention, even though the flora structure remained unchanged from baseline. Compared to FOS, XOS enriched Bifidobacterium at a lower dose, and patients receiving XOS supplementation showed significant improvements in constipation symptoms without side effects such as diarrhea and flatulence.

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Molecular link between dietary fibre, gut microbiota and health

Cited by 130 publications

References 68 publications

The Improvement of Parturition Progress by High Intake of Dietary Fibre in Late Gestation is Associated with the Altered Gut Microbiome and Metabolome in Sows

The Improvement of Parturition Progress by High Intake of Dietary Fibre in Late Gestation is Associated with the Altered Gut Microbiome and Metabolome in Sows

The Gut Microbiota: A Potential Gateway to Improved Health Outcomes in Breast Cancer Treatment and Survivorship

Xylo‐oligosaccharides improve functional constipation by targeted enrichment of Bifidobacterium

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