Molecular landmarks along the axonal route: axonal transport in health and disease

Salinas, Sara; Bilsland, Lynsey G.; Schiavo, Giampietro

doi:10.1016/j.ceb.2008.04.002

Cited by 78 publications

(62 citation statements)

References 65 publications

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“…KLC is a component of kinesin-1, which is a tetrameric motor protein composed of two KLCs and two kinesin heavy chains (KHCs). Kinesin-1 is involved in axonal and dendritic transport of mitochondria; vesicles containing amyloid- precursor protein (APP) or apolipoprotein E receptor 2 (ApoER2); the c-Jun N-terminal kinase interacting proteins (JIPs); other protein complexes; and mRNA granules (Hirokawa and Takemura, 2005;Salinas et al, 2008). Here we show that caytaxin is transported by kinesin in neurites.…”

Section: Introductionmentioning

confidence: 91%

Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains

Aoyama

Hata

Nakao

et al. 2009

Journal of Cell Science

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Section: Introductionmentioning

confidence: 91%

Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains

Aoyama

Hata

Nakao

et al. 2009

Journal of Cell Science

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“…Although the endocytic pathway in epithelial cells is well characterized, the molecular machinery mediating endosomal trafficking in neurons is still poorly understood. Nonetheless, the emerging picture of endosomal trafficking in neurons suggests that different endosomal pools may be involved in the regulation of distinct signaling pathways and polarized distribution of guidance and adhesion molecules (2).…”

Section: Discussionmentioning

confidence: 99%

“…Protein complexes and vesicles must travel long distances to establish and then maintain proper connections between neuronal cell bodies and their targets. Dysfunction of proteins involved in axonal transport has been recently linked to neurodegenerative diseases, revealing a role of axonal transport in neuronal function (1,2). Although the role of molecular motors in axonal transport is now well established, we know little about the nature of the organelles moving in axons and the machinery regulating their transport.…”

mentioning

confidence: 99%

Sunday Driver Interacts with Two Distinct Classes of Axonal Organelles

Abe

Almenar-Queralt

Lillo

et al. 2009

Journal of Biological Chemistry

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The extreme polarized morphology of neurons poses a challenging problem for intracellular trafficking pathways. The distant synaptic terminals must communicate via axonal transport with the cell soma for neuronal survival, function, and repair. Multiple classes of organelles transported along axons may establish and maintain the polarized morphology of neurons, as well as control signaling and neuronal responses to extracellular cues such as neurotrophic or stress factors. We reported previously that the motorbinding protein Sunday Driver (syd), also known as JIP3 or JSAP1, links vesicular axonal transport to injury signaling. To better understand syd function in axonal transport and in the response of neurons to injury, we developed a purification strategy based on anti-syd antibodies conjugated to magnetic beads to identify sydassociated axonal vesicles. Electron microscopy analyses revealed two classes of syd-associated vesicles of distinct morphology. To identify the molecular anatomy of syd vesicles, we determined their protein composition by mass spectrometry. Gene Ontology analyses of each vesicle protein content revealed their unique identity and indicated that one class of syd vesicles belongs to the endocytic pathway, whereas another may belong to an anterogradely transported vesicle pool. To validate these findings, we examined the transport and localization of components of syd vesicles within axons of mouse sciatic nerve. Together, our results lead us to propose that endocytic syd vesicles function in part to carry injury signals back to the cell body, whereas anterograde syd vesicles may play a role in axonal outgrowth and guidance.

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“…Kinesin-driven anterograde transport along microtubules has been shown to play crucial roles in maintaining axonal morphology and function (Goldstein, 2001;Hirokawa and Takemura, 2005;Salinas et al, 2008;Maday et al, 2014). Conventional kinesin (kinesin-1) consists of heavy chain (Kif5a, Kif5b or Kif5c) dimmer and light chains.…”

Section: Introductionmentioning

confidence: 99%

Kinesin-1 sorting in axons controls the differential retraction of arbor terminals

Seno

Ikeno

Mennya

et al. 2016

Journal of Cell Science

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The ability of neurons to generate multiple arbor terminals from a single axon is crucial for establishing proper neuronal wiring. Although growth and retraction of arbor terminals are differentially regulated within the axon, the mechanisms by which neurons locally control their structure remain largely unknown. In the present study, we found that the kinesin-1 (Kif5 proteins) head domain (K5H) preferentially marks a subset of arbor terminals. Time-lapse imaging clarified that these arbor terminals were more stable than others, because of a low retraction rate. Local inhibition of kinesin-1 in the arbor terminal by chromophore-assisted light inactivation (CALI) enhanced the retraction rate. The microtubule turnover was locally regulated depending on the length from the branching point to the terminal end, but did not directly correlate with the presence of K5H. By contrast, F-actin signal values in arbor terminals correlated spatiotemporally with K5H, and inhibition of actin turnover prevented retraction. Results from the present study reveal a new system mediated by kinesin-1 sorting in axons that differentially controls stability of arbor terminals.

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Molecular landmarks along the axonal route: axonal transport in health and disease

Cited by 78 publications

References 65 publications

Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains

Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains

Sunday Driver Interacts with Two Distinct Classes of Axonal Organelles

Kinesin-1 sorting in axons controls the differential retraction of arbor terminals

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