Molecular interactions of esculin with bovine serum albumin and recognition of binding sites with spectroscopy and molecular docking

Qureshi, Mohd Aamir; Akbar, Mahmood; Amir, Mohd; Javed, Saleem

doi:10.1080/07391102.2022.2036238

Cited by 10 publications

(1 citation statement)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the development of new drugs, pharmacokinetics research and pharmacodynamics research are equally important, and have become an important part of drug preclinical research and clinical research (Li et al, 2019). Molecular docking simulation showed that esculin could bind to bovine serum albumin, and Lys‐294, Tyr‐340, Val‐342, Ser‐343, and Trp‐213 were the major residues of bovine serum albumin that formed a binding pocket for esculin (Qureshi, Akbar, Amir, & Javed, 2022). Xu et al used molecular docking simulation to explore the interaction of esculin and human serum albumin.…”

Section: Pharmacokinetics Of Esculinmentioning

confidence: 99%

The pharmacological and pharmacokinetic properties of esculin: A comprehensive review

Lai

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

Cortex fraxini is a widely used traditional Chinese medicine. Esculin is one of the main active ingredients of Cortex fraxini and has attracted more and more attention from scholars. The purpose of the review is to systematically review relevant studies on the pharmacological effects and pharmacokinetic characteristics of esculin to support its further application as therapeutic agents. Pharmacological studies have shown that the anti-inflammatory and anti-oxidative stress effects of esculin are outstanding. This indicates that esculin is promising to be used to treat a variety of diseases closely related to inflammation and oxidative damage. Esculin has anti-diabetic effect, which is closely related to improving pancreas damage, promoting insulin release, and enhancing glucose homeostasis. In addition, esculin has anti-cancer, antibiosis, antivirus, neuroprotection, anti-thrombosis and treating eye diseases properties. Pharmacokinetic studies show that esculin can be quickly and evenly distributed in the body.However, the first pass effect of esculin is serious. In short, esculin is promising to treat many diseases, but further high quality studies are needed to firmly establish the clinical efficacy of esculin.

show abstract

Section: Pharmacokinetics Of Esculinmentioning

confidence: 99%

The pharmacological and pharmacokinetic properties of esculin: A comprehensive review

Lai

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

The Journey of 1-Keto-1,2,3,4-Tetrahydrocarbazole Based Fluorophores: From Inception to Implementation

Mitra¹

2022

J Fluoresc

View full text Add to dashboard Cite

Hydrazone analogs as DNA gyrase inhibitors and antioxidant agents: Structure-activity relationship and pharmacophore modeling

Dammene Debbih,

Mazouz,

Benslama

et al. 2024

J Chem Sci

View full text Add to dashboard Cite

Molecular interactions of esculin with bovine serum albumin and recognition of binding sites with spectroscopy and molecular docking

Cited by 10 publications

References 61 publications

The pharmacological and pharmacokinetic properties of esculin: A comprehensive review

The pharmacological and pharmacokinetic properties of esculin: A comprehensive review

The Journey of 1-Keto-1,2,3,4-Tetrahydrocarbazole Based Fluorophores: From Inception to Implementation

Hydrazone analogs as DNA gyrase inhibitors and antioxidant agents: Structure-activity relationship and pharmacophore modeling

Contact Info

Product

Resources

About