Molecular Insights into the Relationship Between Platelet Activation and Endothelial Dysfunction: Molecular Approaches and Clinical Practice

Kazemi, Niloufar; Bordbar, Armin; Bavarsad, Samaneh Salehipour; Ghasemi, Parisa; Bakhshi, Maryam; Rezaeeyan, Hadi

doi:10.1007/s12033-023-01010-8

Cited by 3 publications

(2 citation statements)

References 144 publications

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“…Fibrinolysis is the decomposition of a thrombosis or clot, and it is tightly controlled by tissue factor plasminogen inhibitor (TFPI), plasminogen activators, plasminogen activator inhibitor-1 (PAI-1), and plasmin [ 48 ]. A healthy endothelium constitutes an anticoagulant and antithrombotic protective layer and secretes an abundance of substances that directly regulate platelet activity, including nitric oxide (NO), prostaglandins, and ectonucleoside triphosphate diphosphate hydrolase-1 (E-NTPDase1) [ 49 , 50 ]. Endothelial cells express TFPI, which limits the effects of tissue factor (TF) and inhibits the TF-mediated overactivation of clotting factors VII and X [ 51 ].…”

Section: Endothelial Dysfunction Promotes Coagulopathymentioning

confidence: 99%

Unraveling the Role of Endothelial Dysfunction in Osteonecrosis of the Femoral Head: A Pathway to New Therapies

Shao,

Wang,

et al. 2024

Biomedicines

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Osteonecrosis of the femoral head (ONFH) is a disabling disease characterized by the disruption of the blood supply to the femoral head, leading to the apoptosis and necrosis of bone cells and subsequent joint collapse. Total hip arthroplasty is not optimal since most patients are young. Multiple risk factors contribute to osteonecrosis, including glucocorticoid (GC) usage, excessive alcohol intake, hypercholesterolemia, and smoking. Continuous stimulation by many variables causes a chronic inflammatory milieu, with clinical repercussions including endothelial dysfunction, leading to thrombosis, coagulopathy, and poor angiogenesis. Immune cells are the primary regulators of inflammation. Innate and adaptive immune cells interact with endothelial cells to hinder the regeneration and repair of bone lesions. An in-depth examination of the pathological drivers of ONFH reveals that endothelial dysfunction may be a major cause of osteonecrosis. Understanding the involvement of endothelial dysfunction in the chronic inflammation of osteonecrosis could aid in the development of possible therapies. This review summarizes the role of endothelial cells in osteonecrosis and further explains the pathophysiological mechanism of endothelial dysfunction in this disease from the perspective of inflammation to provide new ideas for the treatment of osteonecrosis.

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Section: Endothelial Dysfunction Promotes Coagulopathymentioning

confidence: 99%

Unraveling the Role of Endothelial Dysfunction in Osteonecrosis of the Femoral Head: A Pathway to New Therapies

Shao,

Wang,

et al. 2024

Biomedicines

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“…This chronic low-grade inflammation is associated with endothelial dysfunction, oxidative stress, and plaque formation in the arteries, contributing to the development and progression of atherosclerosis. Inflammatory processes in the cardiovascular system increase the risk of coronary and vascular artery disease [11,29,31,37,38].…”

Section: Sdoh and Stress In Womenmentioning

confidence: 99%

The Impact of Stress and Social Determinants on Diet in Cardiovascular Prevention in Young Women

Coppi,

Bucciarelli,

Solodka

et al. 2024

Nutrients

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The prevention of cardiovascular diseases is a fundamental pillar for reducing morbidity and mortality caused by non-communicable diseases. Social determinants, such as socioeconomic status, education, neighborhood, physical environment, employment, social support networks, and access to health care, play a crucial role in influencing health outcomes and health inequities within populations. Social determinants and stress in women are interconnected factors that can significantly impact women’s health and well-being. Pregnancy is a good time to engage young women and introduce them to beneficial behaviors, such as adopting essential life skills, especially diet, and learning stress management techniques. Stress influences diet, and women are more likely to engage in unhealthy eating behaviors such as emotional eating or coping with stress with food. Strong action is needed to improve women’s lifestyle starting at a young age considering that this lays the foundation for a lower cardiovascular risk in adults and the elderly. The objective of this review is to examine cardiovascular primary prevention in young healthy women, focusing particularly on unresolved issues and the influence of social determinants, as well as the correlation with stressors and their influence on diet.

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Association Between Platelet-to-High-Density Lipoprotein Cholesterol Ratio and Cognitive Function in Older Americans: Insights from a Cross-Sectional Study

Zheng,

Zhang,

Qin

et al. 2024

Preprint

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Aims The main aim of this study was to explore the correlation between the platelet/high-density lipoprotein cholesterol ratio (PHR) and cognitive function in elderly individuals from the United States. Methods This investigation leveraged data encompassing 2299 participants, all aged 60 years and above, from the National Health and Nutrition Examination Survey conducted from 2011 to 2014. Inclusion criteria were based on the availability of complete datasets for PHR and cognitive function assessments. The analytical approach incorporated multivariate logistic regression to discern the association between PHR and cognitive impairment. Additionally, the study employed restricted cubic splines (RCS) to explore potential non-linear relationships and subgroup analyses to identify variations in the observed associations across different demographic and clinical subgroups. Results In the fully adjusted model, an increment of 10 units in PHR was associated with a decline of 0.014 in cognitive scores (β=-0.014, 95% CI: -0.025, -0.002; P<0.05). Compared to the lowest quartile, participants in the highest quartile exhibited a 38.4% increased prevalence of cognitive impairment per one-unit increase in PHR (OR=1.384, 95% CI: 1.012, 1.893; P<0.05). Subgroup analysis revealed consistent results regarding the relationship between PHR and cognitive impairment across all subgroups. A non-linear relationship between PHR and cognitive impairment was observed using RCS, indicating that an increase in PHR above 111.49 significantly elevated the incidence of cognitive impairment (P<0.05). Conclusions Our study proves that higher PHR is linked to a greater risk of cognitive decline in the U.S. elderly population, warranting consideration in clinical assessments and interventions.

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Molecular Insights into the Relationship Between Platelet Activation and Endothelial Dysfunction: Molecular Approaches and Clinical Practice

Cited by 3 publications

References 144 publications

Unraveling the Role of Endothelial Dysfunction in Osteonecrosis of the Femoral Head: A Pathway to New Therapies

Unraveling the Role of Endothelial Dysfunction in Osteonecrosis of the Femoral Head: A Pathway to New Therapies

The Impact of Stress and Social Determinants on Diet in Cardiovascular Prevention in Young Women

Association Between Platelet-to-High-Density Lipoprotein Cholesterol Ratio and Cognitive Function in Older Americans: Insights from a Cross-Sectional Study

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