volume 50, issue 3, P233-238 1991
DOI: 10.1038/clpt.1991.131
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Abstract: Introduction and brief historyIt is intriguing that between 5% and 10% of white persons lack an enzyme expressed in liver and brain and yet apparently suffer no ill effects, reproduce, and generally live a normal life. This contrasts with genetic diseases such as the thalassemias, phenylketonuria, cystic fibrosis, and others that have dire health consequences. Such are the drug metabolism polymor-phism~ that have been described for N-acetyltransferases,' a form of glutathione S-tran~ferase,~ certain cytochrom…

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