Molecular genetic studies on the compatibility of HLA class II alleles in patients with unexplained recurrent miscarriage in the Japanese population

Takakuwa, Koichi; Honda, Keisuke; Yokoo, Tomokazu; Hataya, Isao; Takao, Masaki; Tanaka, Kenichi

doi:10.1016/j.clim.2005.07.011

Cited by 20 publications

(14 citation statements)

References 29 publications

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“…Ober et al [16] support such a conclusion by suggesting that HLA-DQA1-compatible fetuses may be aborted very early in pregnancy. Takakuwa et al, who were initially skeptical [17], more recently concluded [18 ]that compatibility of HLA class II antigens between husband and wife may be involved in the genesis of unexplained recurrent pregnancy loss. …”

Section: Discussionmentioning

confidence: 99%

Gestational Dermatosis Shortly after Implantation Associated with Parental Class II HLA Compatibility and Maternal Immune Activation: Preliminary Report of a Prospective Case Series

Gleicher

Barad²

2011

Dermatology

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Background: Pregnancy represents a semiallograft, subject to similar immune responses as allogeneic organ transplants. Tolerance of pregnancy appears best with maximal class II HLA heterogeneity between mother and father, while compatibilities are associated with increased pregnancy loss and maternal autoimmunity. Tolerance abnormalities often involve skin reactions. Abnormalities in tolerance of the fetal graft may do the same. Objective: To define the characteristics of a newly described dermatosis in very early pregnancy. Methods: Prospective case series of 7 couples/12 clinical episodes. Results: The dermatosis was observed in 7 out of 285 women undergoing in vitro fertilization (IVF; 2.5%; 95% CI 0.66–4.26%) and in 12 out of 277 total IVF cycles reaching embryo transfer (4.3%; 95% CI 1.93–6.73%). Prior to IVF all women reported autoimmune clinically significant allergies. All but 1 couple demonstrated class II HLA compatibility. Two of 4 pregnancies miscarried. All rashes erupted within days from embryo implantation. Conclusions: The ‘implantation rash’ reported here is uncommon but not rare. It may be the consequence of abnormal maternal immune responses to embryo implantation in women with prior immune activation, associated with class II HLA compatibility between parents. Further prospective studies are required to better define this condition.

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Section: Discussionmentioning

confidence: 99%

Gestational Dermatosis Shortly after Implantation Associated with Parental Class II HLA Compatibility and Maternal Immune Activation: Preliminary Report of a Prospective Case Series

Gleicher

Barad²

2011

Dermatology

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“…The PCR-RFLP method has been used for allelespecific HLA-DQB1 typing, because it has the additive advantage of providing a step where the allele-specific characteristic of the PCR product is confirmed [34,35]. Thus, we performed PCR-RFLP analysis using amplified product from the DB130 ϩ and DB131 Ϫ primer set.…”

Section: Discussionmentioning

confidence: 99%

Sequence Analysis of Major Histocompatibility Complex Class-II DQB1 (Patr-DQB1) Alleles in Chimpanzees by Polymerase Chain Reaction–Based Methods

Bak¹,

Ishii²,

Omatsu³

et al. 2006

Human Immunology

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“…1А, 2А -женщины с сохранным ответом в СКЛ; 1Б, 2В -женщины со сниженным ответом в СКЛ. [21,36]. Запуск иммун-ного ответа возможен только при достаточных различиях партнеров по HLA-антигенам, а сход-ство свыше 25% расценивается как неблагопри-ятный фактор для репродукции [14,36].…”

Section: т 16 №unclassified

“…[21,36]. Запуск иммун-ного ответа возможен только при достаточных различиях партнеров по HLA-антигенам, а сход-ство свыше 25% расценивается как неблагопри-ятный фактор для репродукции [14,36]. Соглас-но полученным нами данным, снижение ответа в СКЛ регистрировалось только у половины жен-щин с дефицитом БФ, тогда как у другой поло-вины отсутствие БФ не сопровождалось низким ответом МНК на стимуляции лимфоцитами пар-тнера.…”

Section: т 16 №unclassified

Paternal Lymphocyte Alloimmunization in the Treatment of Infertility: A New Look at an Old Problem

Khonina¹,

Ладыгина²,

Вятчинина³

et al. 2014

Med.Imm.Rus

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Molecular genetic studies on the compatibility of HLA class II alleles in patients with unexplained recurrent miscarriage in the Japanese population

Cited by 20 publications

References 29 publications

Gestational Dermatosis Shortly after Implantation Associated with Parental Class II HLA Compatibility and Maternal Immune Activation: Preliminary Report of a Prospective Case Series

Gestational Dermatosis Shortly after Implantation Associated with Parental Class II HLA Compatibility and Maternal Immune Activation: Preliminary Report of a Prospective Case Series

Sequence Analysis of Major Histocompatibility Complex Class-II DQB1 (Patr-DQB1) Alleles in Chimpanzees by Polymerase Chain Reaction–Based Methods

Paternal Lymphocyte Alloimmunization in the Treatment of Infertility: A New Look at an Old Problem

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