Molecular genetic studies of HLA-DRB1 alleles in patients with unexplained recurrent abortion in the Japanese population

Abstract

These findings suggest that HLA-DRB1*1502 might be a risk allele for unexplained recurrent abortion in the Japanese population.

Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients

“…In decidua, PIBF is known as a target gene of hsa-miR 520h (Supplementary Table 3), and PIBF can mediate progesterone-induced suppression of decidual lymphocyte cytotoxicity (Laskarin et al 2002). We predicted HLA-DPB1 as a target gene of hsa-miR-520f, which was low expressed in villus (Supplementary Table 3), and just as Takakuwa et al (2003) reported HLA-DPB1 might be a risk allele for unexplained recurrent abortion in the Japanese population. From target gene results (Supplementary Table 3), hsa-miR-519a-1 upregulated in the decidua of RSA patients could target 3 0 UTR of CD69; therefore, intracellular expression of CD69 in endometrial and peripheral T cells represents a useful marker in women with recurrent miscarriage (Ramhorst et al 2003).…”

Immunological Analogy Between Allograft Rejection, Recurrent Abortion and Pre-Eclampsia – the Same Basic Mechanism?

“…Another possible factor capable of enhancement of fgl2 activity might be decreased HO expression observed in invasive trophoblast, syncytiotrophoblast and endothelial cells of decidual vessels of patients with spontaneous abortion [185]. The most important reason for altered Th1/Th2 balance in cases of recurrent miscarriage is not precisely known, however, reduced expression of HLA-G isoforms on trophoblast or relationship between high production of Th1 cytokines and certain genotypes could provide some explanation [186,187,188,189,190,191]. Recently, the size of a microsatellite polymorphism of HO-1 gene has been found to correlate with RA [192].…”

Increased Plasma Concentrations of Antiprothrombin Antibodies in Women with Recurrent Spontaneous Abortions

“…Recurrent spontaneous abortion (RSA) 3 is usually defined as the loss of Ն3 consecutive pregnancies at Ͻ20 weeks of pregnancy (1 ). Among the risk factors for RSA [chromosomal (2 ), genetic (3 ), anatomical (4 ), endocrinological (5 ), and placental anomalies (6 ); infection (7 ); and stress (8 )], thrombophilic conditions attributable to venous thromboembolism, as in the case of antiphospholipidantibody syndrome (APS) (9 -12 ), have a relevant role.…”