Molecular-genetic and cytogenetic characteristics of sporadic kidney cancer: literature review

Popov, S.V.; Guseynov, R. G.; Skryabin, O.N.; Perepelitsa, V. V.; Davydov, A V; Barchitdinov, R.S.; Katunin, A.S.; Mirzabekov, M.M.

doi:10.17650/1726-9776-2022-18-3-107-115

Onkourologiâ

2022

DOI: 10.17650/1726-9776-2022-18-3-107-115

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Molecular-genetic and cytogenetic characteristics of sporadic kidney cancer: literature review

S.V. Popov¹,

R. G. Guseynov

O.N. Skryabin³

et al.

Abstract: To compile this literature review, we studied at least 100 publications devoted to the genetic basis of clear cell, papillary, and chromophobic sporadic kidney cancer pathogenesis. Each of them considered the role of somatic gene and chromosomal mutations in the initiation, promotion, and tumor progression of sporadic renal cell carcinoma, emphasized the importance of determining the mutagenic profile of renal cell carcinoma for the future fate of patients.

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2024

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THE IMPORTANCE OF P16 GENE EXPRESSION AS A FACTOR OF TUMOR BLAST CELL TRANSFORMATION (literature review)

Subbotina,

Guseynov,

Gol'cova

et al. 2024

Clinical Medicine and Pharmacology

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For a more accurate prediction of tumor behavior and individualization of treatment approach, it is necessary to improve new methods of early diagnosis of precancerous conditions. The article provides an overview of the modern understanding of the mechanisms of gene p16 expression as a factor in tumor growth. Data on the relevance of studying the pathogenesis of tumor blast transformation in invasive breast cancer are presented. These tumors require the combined interdisciplinary work of highly qualified specialists and ultra-modern technologies to achieve a positive result. The link between the formation of malignant breast tumors and human papillomavirus is described. The purpose of this study was to review the futuristically significant immunohistochemical analysis of p16 in patients of different age groups with common cervical cancer and breast cancer. The possibility of using the determination of p16 expression as a prognostic marker for breast cancer is shown, as well as the results of studying the expression of p16 and p53 in triple-negative breast cancer. The data reflecting the dependence of the suppressor function efficiency on the localization of p16 expression in squamous cell carcinoma of the cervix are analyzed. The dependence of p16INK4a expression on the severity of malignant cervical lesions is indicated, and the effect of chemotherapy on p16 expression is considered. By studying and applying information on the ontogenetic variability of the p16 gene, it is possible to significantly increase the accuracy of predicting the clinical and pathomorphological course of cancer of any nature of occurrence and to select adequate therapy: gene, chemotherapy, radiation therapy.

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THE IMPORTANCE OF P16 GENE EXPRESSION AS A FACTOR OF TUMOR BLAST CELL TRANSFORMATION (literature review)

Subbotina,

Guseynov,

Gol'cova

et al. 2024

Clinical Medicine and Pharmacology

View full text Add to dashboard Cite

show abstract

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Molecular-genetic and cytogenetic characteristics of sporadic kidney cancer: literature review

Cited by 1 publication

References 83 publications

THE IMPORTANCE OF P16 GENE EXPRESSION AS A FACTOR OF TUMOR BLAST CELL TRANSFORMATION (literature review)

THE IMPORTANCE OF P16 GENE EXPRESSION AS A FACTOR OF TUMOR BLAST CELL TRANSFORMATION (literature review)

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