2015
DOI: 10.1590/s1415-475738320150039
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Abstract: Developmental processes and their results, morphological characters, are inherited through transmission of genes regulating development. While there is ample evidence that cis-regulatory elements tend to be modular, with sequence segments dedicated to different roles, the situation for proteins is less clear, being particularly complex for transcription factors with multiple functions. Some motifs mediating protein-protein interactions may be exclusive to particular developmental roles, but it is also possible… Show more

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Cited by 5 publications
(74 citation statements)
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References 60 publications
(74 reference statements)
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“…As a consequence, this gene family is often recognized as a major agent for diversification of metazoan body plans [ 19 , 20 ]. Evaluation of molecular evolutionary patterns of Hox genes in the context of independent origins of equivalent phenotypes, however, remains relegated [but see [ 32 ] for a recent study on the topic].…”
Section: Introductionmentioning
confidence: 99%
“…Shh plays a crucial role in regulating vertebrate organogenesis, such as the development of digits on limbs. A different evolutionary rate of Shh was not found, as expected, which is likely because the mechanism of limb reduction in reptiles is regulated by other related genes, such as HoxA13 (Singarete et al 2015). The overall branches of Shh rejected the two-ratio model, suggesting that the reptilian Shh gene evolved at a relatively stable rate.…”
Section: Discussionmentioning
confidence: 51%
“…Molecular evolution of HoxA13 and the multiple origins of limbless morphologies in amphibians and reptiles (Singarete et al., )…”
Section: Latin America: a Living Laboratory For Evo‐devo Researchmentioning
confidence: 99%
“…Another example of extreme body shape transformation that has been studied using nonmodel organisms is the convergent evolution of snakelike forms in Neotropical Squamata (lizards, snakes, and amphisbaenians), which involve limb reduction or loss along with an increase in the number of trunk vertebrae. Comparative anatomical and molecular studies suggest that convergent forms do not necessarily involve the same evolutionary changes in developmental processes and genetic pathways (Waters, ; Roscito et al., ; Singarete et al., ). Changes in the anatomy of the musculoskeletal system associated with limbless morphologies and epigenetic effects of reduced mobility on limb development have also been studied for anurans (Abdala and Ponssa, ; Abdala et al., ).…”
Section: A Selection Of Evo‐devo Topics Currently Addressed By Latin mentioning
confidence: 99%
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