2016
DOI: 10.1093/cid/ciw570
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Abstract: Our findings strongly suggest that the aerosol route of infection and transmission is predominant and that HHCs contribute to the infection risk to themselves and probably to others.

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Cited by 75 publications
(92 citation statements)
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“…Human leprosy still poses a considerable health threat in developing countries where transmission is generally assumed to take place via aerosol droplets from nasal cavities of untreated M. leprae infected individuals to their close contacts(8, 9). However, nonhuman animal and environmental sources have also been suggested to play a role in the pathogen’s dissemination(8).…”
Section: Discussionmentioning
confidence: 99%
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“…Human leprosy still poses a considerable health threat in developing countries where transmission is generally assumed to take place via aerosol droplets from nasal cavities of untreated M. leprae infected individuals to their close contacts(8, 9). However, nonhuman animal and environmental sources have also been suggested to play a role in the pathogen’s dissemination(8).…”
Section: Discussionmentioning
confidence: 99%
“…Human leprosy still poses a considerable health threat in developing countries where transmission is generally assumed to take place via aerosol droplets from nasal cavities of untreated M. leprae infected individuals to their close contacts(8, 9). However, nonhuman animal and environmental sources have also been suggested to play a role in the pathogen’s dissemination(8). As paleopathological evidence of leprosy in pre-Columbian America is lacking, leprosy was very likely introduced to the continent by European colonists or the African slave route(23) also resulting in transmission to armadillos.…”
Section: Discussionmentioning
confidence: 99%
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“…A Organização Mundial da Saúde (OMS) define como estratégia principal para o controle da hanseníase o diagnóstico precoce associado ao tratamento oportuno de todos os casos 7 . Nesse sentido, ao reconhecer o risco acrescido em contatos de casos de hanseníase de infecção por Mycobacterium leprae e adoecimento, reforça-se que as ações de vigilância devem ser priorizadas nessa população, ocorrendo de forma contínua e sistemática 3,7,8,9,10 . O Ministério da Saúde do Brasil definia contato, até 2016, como qualquer pessoa que residia ou tinha residido com o caso novo de hanseníase no âmbito do domicílio nos últimos cinco anos anteriores ao diagnóstico da doença 8 .…”
Section: Introductionunclassified
“…The precise mode of transmission of leprosy remains uncertain but probably involves human-to-human contact through respiratory droplets (29,30,(45)(46)(47) or through blood transfusion (48). Ecological data suggest that environmental factors, such as trauma or skin breaks during soil and water exposures, insect vectors, free-living amoebas, and animal reservoirs (e.g., armadillos, squirrels, felines, or other animals), influence leprosy transmission (39,47,(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63).…”
Section: Mycobacterial Species As Human Pathogensmentioning
confidence: 99%