Molecular Epidemiology of Laguna Negra Virus, Mato Grosso State, Brazil

Rosa, Elizabeth Salbé Travassos da; Medeiros, Daniele B. A.; Nunes, Márcio Roberto Teixeira; Simith, Darlene B.; Pereira, Armando de Souza; Elkhoury, Mauro R.; Santos, Elizabeth Davi; Lavocat, Marília; Marques, A. A. R; Via, Alba Valéria Gomes de Melo; Kohl, Vânia A.; Terças, Ana Cláudia Pereira; D’Andrea, Paulo Sérgio; Bonvicino, Cibele Rodrigues; Lemos, Elba Regina Sampaio de; Vasconcelos, Pedro F.C.

doi:10.3201/eid1806.110948

Cited by 28 publications

(20 citation statements)

References 14 publications

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“…However, it has not been tested whether all of these Akodon species act as natural reservoirs, maintaining the infection in the population by horizontal transmission, or if it is the result of spill-over infection from the primary rodent host into other species of the same genus. The same situation was observed for Laguna Negra, which was originally isolated from specimens of Calomys laucha from Paraguay (Johnson et al, 1997) and identified as the epidemiological agent that causes HPS cases in Bolivia, western Paraguay, western Brazil and northern Argentina (Johnson et al, 1997;Levis et al, 2004;Travassos da Rosa et al, 2012). Laguna Negra was also detected in rodents originally named Calomys callosus (Levis et al, 2004), later identified molecularly as C. fecundus (R. E. Gonzalez-Ittig, personal communication) and in Calomys callidus (Travassos da .…”

Section: Hantavirus -Host Relationshipssupporting

confidence: 59%

Preferential host switching and its relation with Hantavirus diversification in South America

Rivera

González‐Ittig

Gardenal

2015

Journal of General Virology

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In recent years, the notion of co-speciation between Hantavirus species and their hosts was discarded in favour of a more likely explanation: preferential host switching. However, the relative importance of this last process in shaping the evolutionary history of hantaviruses remains uncertain, given the present limited knowledge not only of virus-host relationships but also of the pathogen and reservoir phylogenies. In South America, more than 25 hantavirus genotypes were detected; several of them act as aetiological agents of hantavirus pulmonary syndrome (HPS). An understanding of the diversity of hantaviruses and of the processes underlying host switching is critical since human cases of HPS are almost exclusively the result of human-host interactions. In this study, we tested if preferential host switching is the main process driving hantavirus diversification in South America, by performing a co-phylogenetic analysis of the viruses and their primary hosts. We also suggest a new level of amino acid divergence to define virus species in the group. Our results indicate that preferential host switching would not be the main process driving virus diversification. The historical geographical proximity among rodent hosts emerges as an alternative hypothesis to be tested.

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Section: Hantavirus -Host Relationshipssupporting

confidence: 59%

Preferential host switching and its relation with Hantavirus diversification in South America

Rivera

González‐Ittig

Gardenal

2015

Journal of General Virology

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“…Molecular identification of pathogens, their vectors, and their reservoirs is one of the expected applications of the DNA barcoding initiative. Knowledge of the exact species that is (are) carrying harmful pathogens is essential to studies of the factors leading to occurrences [ 1 , 2 ], pathogen proliferation [ 3 ], and transmission between animal vectors [ 4 – 6 ], as well as for epidemiological inferences as a whole.…”

Section: Introductionmentioning

confidence: 99%

DNA Barcoding of Sigmodontine Rodents: Identifying Wildlife Reservoirs of Zoonoses

et al. 2013

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Species identification through DNA barcoding is a tool to be added to taxonomic procedures, once it has been validated. Applying barcoding techniques in public health would aid in the identification and correct delimitation of the distribution of rodents from the subfamily Sigmodontinae. These rodents are reservoirs of etiological agents of zoonoses including arenaviruses, hantaviruses, Chagas disease and leishmaniasis. In this study we compared distance-based and probabilistic phylogenetic inference methods to evaluate the performance of cytochrome c oxidase subunit I (COI) in sigmodontine identification. A total of 130 sequences from 21 field-trapped species (13 genera), mainly from southern Brazil, were generated and analyzed, together with 58 GenBank sequences (24 species; 10 genera). Preliminary analysis revealed a 9.5% rate of misidentifications in the field, mainly of juveniles, which were reclassified after examination of external morphological characters and chromosome numbers. Distance and model-based methods of tree reconstruction retrieved similar topologies and monophyly for most species. Kernel density estimation of the distance distribution showed a clear barcoding gap with overlapping of intraspecific and interspecific densities < 1% and 21 species with mean intraspecific distance < 2%. Five species that are reservoirs of hantaviruses could be identified through DNA barcodes. Additionally, we provide information for the description of a putative new species, as well as the first COI sequence of the recently described genus Drymoreomys. The data also indicated an expansion of the distribution of Calomys tener. We emphasize that DNA barcoding should be used in combination with other taxonomic and systematic procedures in an integrative framework and based on properly identified museum collections, to improve identification procedures, especially in epidemiological surveillance and ecological assessments.

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“…The circumstances of infection experienced by children from each Mato Grosso region are distinct from other ones, considering that they all have a routinely contact with wild rodents. The Central North region of Mato Grosso is devoted to agricultural activities, with extensive farms practicing direct planting and with two circulating hantavirus genotypes, Castelo dos Sonhos ( Oligoryzomys utiairitensis ) and Laguna Negra ( Calomys Callidus ) 35 , 36 .…”

Section: Discussionmentioning

confidence: 99%

Hantavirus pulmonary syndrome in children: case report and case series from an endemic area of Brazil

Terças-Trettel

Melo

Bonilha

et al. 2019

Rev. Inst. Med. trop. S. Paulo

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Hantavirus Cardiopulmonary Syndrome (HCPS) is an important emergent zoonosis associated with wild rodents in Brazil, where this viral infection in children is generally rare. We present HCPS in a child from the Pantanal Biome and a review of all reported pediatric cases in Mato Grosso State, an endemic area for HCPS in Brazil. The investigation used the Information System for Notifiable Diseases database (SINAN). A 12-year-old boy was hospitalized with fever and respiratory failure and hantavirus IgM and IgG antibodies were detected by ELISA in serum samples. During the period of 1999 to 2016, 32 HCPS pediatric cases confirmed by serology were reported to SINAN with a mortality rate of 34.4%. The possibility of hantavirus infection in children with acute febrile illness associated with respiratory failure should be considered mainly in recognized endemic areas as Mato Grosso State, contradicting a hypothesis that children are more protected from lung involvement.

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Molecular Epidemiology of Laguna Negra Virus, Mato Grosso State, Brazil

Cited by 28 publications

References 14 publications

Preferential host switching and its relation with Hantavirus diversification in South America

Preferential host switching and its relation with Hantavirus diversification in South America

DNA Barcoding of Sigmodontine Rodents: Identifying Wildlife Reservoirs of Zoonoses

Hantavirus pulmonary syndrome in children: case report and case series from an endemic area of Brazil

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